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14.9 17.10 Resource Evidence - Content

Responsible Owner: Clinical Decision Support icon Work Group Maturity Level : 0   Trial Use Normative Security Category : Business Compartments : Not linked to any No defined compartments

The Evidence resource describes Resource provides a machine-interpretable expression of an evidence concept including the conditional state (population and any exposures being compared within evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the population) statistics, and outcome (if specified) that the knowledge (evidence, assertion, recommendation) is about. certainty of this evidence.

14.9.1 17.10.1 Scope and Usage

The scope Evidence Resource enables the expression of the Evidence resource is to describe most granular form of evidence, such as the conditional state (population and exposures being considered or compared within actual quantitative results of a population) with study or without scientific analysis.

Human-readable summaries of the outcomes that knowledge (evidence, Evidence Resource may be expressed in description, assertion, recommendation) and note elements. The description element is about. typically used for the primary expression. The Evidence resource assertion element is a less commonly bundled series used and is typically used for interpretive expression. The note element may be used for any number of evidence variables from explanatory, variant, or related comments.

The variableDefinition element is used to describe what the "PICO" specification of medical knowledge: Population - evidence is about. Each variable defined must be assigned a variable role which signals how that variable is used in the population statistics within which exposures the Evidence Resource. The variable definition may be expressed in human-readable form (with a description element) and/or expressed in computable form by referencing Group or EvidenceVariable Resources. In general, Group Resources are used to define populations and outcomes EvidenceVariable Resources are being considered Intervention - used to define measured variables (exposures, outcomes, and covariates). The variableDefinition element allows expression of the conditional state or exposure state being described for which one is expressing observed variable and the risk intended variable. In many forms of or effect on an outcome Comparison - expression the alternative conditional state or alternative exposure state when one Evidence is comparing states interpreted for a specific context and recognition of both observed and intended variables is important for understanding the effect on an outcome Outcome - applicability and certainty of the result or effect evidence.

The heart of an intervention or exposure in a population PICO (and its variants like PECO or PICOT) the evidence is the statistic. The statistic BackboneElement provides a universal acronym used in evidence-based medicine communities to clearly express research questions machine-interpretable expression of a statistic, including the quantity; unit of measure; classification of statistic type; sample size; attributes such as confidence intervals, p values, and heterogeneity estimates; and statistic model characteristics. An Evidence Resource may contain more than one statistic, in which case each statistic matches the same combination of variable definitions.

Because a statistic can rarely be interpreted without knowing how it was obtained, the Evidence Resource enables expression of the studyDesign . For evidence findings. The derived from synthesis of evidence, the Evidence resource allows Resource enables expression of the higher-order concept for recommendations synthesisType .

The certainty element provides a machine-interpretable expression of certainty, confidence or quality of the resource in healthcare where multiple outcomes are considered, which it is included. The certainty element can express overall certainty and certainty of any subcomponent concepts using codeable concepts from structured rating systems. The certainty element enables machine-to-machine communication of the higher-order concept/combination for framing research questions. certainty of evidence.

14.9.2

17.10.2 Boundaries and Relationships

The Evidence resource references Resource is the central atomic component for the Evidence-related Resources. The Evidence Resource may reference multiple Group and EvidenceVariable resource two or more times Resources; in these cases, the Group and EvidenceVariable Resources to which an Evidence Resource points does not refer back to clearly specify the relationship among Evidence. In the context of evidence variable concepts in framing synthesis, a research question, List Resource may reference Evidence Resources where the List Resource is used to define the set of evidence assertion, or recommendation. being synthesized.

17.10.3 References to this Resource

14.9.3 17.10.4 Resource Content

Structure

A research context or question 0..1 Title Subordinate title markdown Annotation Intended jurisdiction for evidence (if applicable) date When 0..* ContactDetail ContactDetail RelatedArtifact What population? Σ What outcome?
Name Flags Card. Type Description & Constraints      Filter: Filters doco
. . Evidence I TU N DomainResource Single evidence bit
+ Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation

Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension
Interfaces Implemented: MetadataResource
. . . url Σ C 0..1 uri Canonical identifier for this evidence, represented as a globally unique URI (globally unique)
+ Warning: URL should not contain | or # - these characters make processing canonical references problematic
. . . identifier Σ 0..* Identifier Additional identifier for the evidence summary

. . . version Σ 0..1 string Business version of the evidence this summary
. . name . versionAlgorithm[x] Σ I 0..1 How to compare versions
Binding: Version Algorithm ( Extensible )
. . . . versionAlgorithmString string Name for this evidence (computer friendly)
. . . . versionAlgorithmCoding Coding
. . . title name Σ C 0..1 string Name for this evidence (human summary (machine friendly)
. . . shortTitle title Σ T 0..1 string Name for use in informal contexts this summary (human friendly)
. . . subtitle citeAs 0..1 string markdown Display of the how to cite this Evidence
. . . status ?! Σ 1..1 code draft | active | retired | unknown
Binding: PublicationStatus ( Required )
. . . date experimental 0..1 Σ boolean For testing only - never for real usage
0..1
. . . date Σ 0..1 dateTime Date last changed
. . . approvalDate 0..1 date When the summary was approved by publisher
. . . lastReviewDate 0..1 date When the summary was last reviewed by the publisher
... author Σ 0..* ContactDetail Who authored the content

0..1
. . . publisher Σ T 0..1 string Name of the publisher publisher/steward (organization or individual)
. . . contact Σ 0..* ContactDetail Contact details for the publisher

. . description . recorder 0..* Σ ContactDetail Who entered the data for the evidence

0..1
. . . editor Natural language description of 0..* ContactDetail Who edited the evidence content

. . note . reviewer 0..* ContactDetail Who reviewed the content

0..*
. . . endorser 0..* ContactDetail Who endorsed the content
Used for footnotes or explanatory notes
. . . useContext Σ 0..* UsageContext The context that the content is intended to support

. . jurisdiction . purpose 0..1 Σ markdown Why this Evidence is defined
. . . copyright 0..1 markdown Intellectual property ownership, may include restrictions on use
... copyrightLabel T 0..1 string Copyright holder and year(s)
... relatesTo 0..* BackboneElement Relationships to other Resources

.... type 1..1 CodeableConcept documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes
Binding: Artifact Relationship Type icon Jurisdiction ( Extensible )
. . . . target[x] 1..1 The artifact that is related to this Evidence
. . . . copyright . targetUri uri
. . . . . targetAttachment Attachment
. . . . . targetCanonical 0..1 canonical ( Any )
..... targetReference Reference ( Any )
..... targetMarkdown markdown Use and/or publishing restrictions
. . approvalDate . description Σ T 0..1 markdown date Description of the particular summary
... assertion When T 0..1 markdown Declarative description of the evidence was approved by publisher Evidence
. . lastReviewDate . note 0..* Annotation Footnotes and/or explanatory notes

0..1
. . . variableDefinition When 0..* BackboneElement Description, classification, and definition of a single variable

.... description 0..1 markdown A text description or summary of the evidence was last reviewed variable
. . . . effectivePeriod note 0..* Annotation Footnotes and/or explanatory notes

.... variableRole Σ 1..1 code population | exposure | outcome | covariate
Binding: Evidence Variable Role ( Required )
.... roleSubtype 0..1 CodeableConcept Period Sub-classification of the role of the variable
Binding: EvidenceVariableRoleSubtype icon ( Example )
. . . . comparatorCategory 0..1 string The reference value used for comparison
.... observed Σ 0..1 Reference ( Group | EvidenceVariable ) Definition of the evidence is expected actual variable related to be used the statistic(s)
. . . topic . intended 0..1 Reference ( Group | EvidenceVariable ) Definition of the intended variable related to the Evidence
. . . . directnessMatch 0..1 CodeableConcept low | moderate | high | exact
Binding: EvidenceDirectness icon ( Example )
... synthesisType 0..* CodeableConcept The category design of the Evidence, such as Education, Treatment, Assessment, etc. synthesis (combination of studies) that produced this evidence
Binding: StatisticSynthesisType icon DefinitionTopic ( Example )

. . . author studyDesign 0..* CodeableConcept The design of the study that produced this evidence
Binding: Study Design ( Extensible )

. . . statistic 0..* BackboneElement ContactDetail Values and parameters for a single statistic

.... description Who authored 0..1 markdown A natural language summary of the content statistic
. . . . editor note 0..* Annotation Footnotes and/or explanatory notes

0..*
. . . . statisticType Who edited the content Σ 0..1 CodeableConcept Type of statistic, e.g., relative risk
Binding: StatisticStatisticType icon ( Example )
. . . . category 0..1 CodeableConcept Associated category for categorical variable
.. . . reviewer quantity Σ 0..1 Quantity Statistic value
0..*
. . . . numberOfEvents Who reviewed 0..1 unsignedInt The number of events associated with the content statistic
. . . . numberAffected 0..1 unsignedInt The number of participants affected
.... sampleSize 0..1 BackboneElement Count of participants in the study sample
. . . . . description 0..1 markdown Textual description of sample size for statistic
... . . endorser note 0..* Annotation Footnote or explanatory note about the sample size

. . . . . numberOfStudies 0..1 unsignedInt Number of contributing studies
..... numberOfParticipants 0..1 unsignedInt Total number of participants
..... knownDataCount 0..1 unsignedInt Number of participants with known results for measured variables
..... numberAnalyzed 0..1 unsignedInt Total number of participants who were analayzed
.... attributeEstimate 0..* BackboneElement ContactDetail An attribute of the Statistic

..... description Who endorsed 0..1 markdown Textual description of the content attribute estimate
. . . . . relatedArtifact note 0..* Annotation Footnote or explanatory note about the estimate

0..*
. . . . . type Additional documentation, citations, etc. 0..1 CodeableConcept The type of attribute estimate, e.g., confidence interval or p value
Binding: StatisticAttributeEstimateType icon ( Example )
. . . . exposureBackground . quantity 0..1 Σ Quantity The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
. . . . . level 0..1 decimal Level of confidence interval, e.g., 0.95 for 95% confidence interval
..... range 0..1 Range Lower and upper bound values of the attribute estimate
..... attributeEstimate 0..* see attributeEstimate A nested attribute estimate; which is the attribute estimate of an attribute estimate

.... modelCharacteristic 0..* BackboneElement An aspect of the statistical model

..... code 1..1 CodeableConcept Model specification
Binding: Statistic Model Code icon Reference ( EvidenceVariable Example )
. . . . . value[x] 0..1 The specific value (when paired with code)
. . . . . exposureVariant . valueQuantity SimpleQuantity
. . . . . . valueRange Range
. . . . . . valueCodeableConcept CodeableConcept
. . . . . intended 0..1 boolean The plan for analysis
..... applied 0..1 boolean This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
..... variable 0..* BackboneElement A variable adjusted for in the adjusted analysis

...... variableDefinition 1..1 Reference ( Group | EvidenceVariable ) Description and definition of the variable
What exposure?
. . . . . . handling 0..1 CodeableConcept boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
Binding: Evidence Variable Handling Example ( Example )
. . . . . . valueCategory 0..* CodeableConcept Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable

. . . . . . valueQuantity 0..* Quantity Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable

.... . outcome . valueRange 0..* Σ Range Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable

. . . . . attribute 0..* see attributeEstimate An attribute of the model characteristic

... certainty 0..* BackboneElement Certainty or quality of the evidence

.... description 0..1 markdown Textual description of certainty
.... note 0..* Annotation Footnotes and/or explanatory notes

.... type 0..1 CodeableConcept Aspect of certainty being rated
Binding: Evidence Certainty Type icon Reference ( EvidenceVariable Example )
. . . . rating 0..1 CodeableConcept Assessment or judgement of the aspect
Binding: StatisticCertaintyRating icon ( Example )
. . . . rater 0..* string Individual or group who did the rating

.... subcomponent 0..* see certainty A domain or subdomain of certainty


doco Documentation for this format icon

See the Extensions for this resource

UML Diagram ( Legend )

Evidence ( DomainResource ) + MetadataResource An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence summary is stored on different servers url : uri [0..1] A formal identifier that is used to identify this evidence summary when it is represented in other formats, or referenced in a specification, model, design or an instance identifier : Identifier [0..*] The identifier that is used to identify this version of the evidence summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a sequence version consistent with the Decision Support Service specification, use : string [0..1] Indicates the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer mechanism used to the Decision Support Service specification. Note that a version compare versions to determine which is required for non-experimental active artifacts more current version versionAlgorithm[x] : string DataType [0..1] « string | Coding ; null (Strength=Extensible) VersionAlgorithm + » A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation name : string [0..1] « This element has or is affected by some invariants C » A short, descriptive, user-friendly title for the evidence summary title : string [0..1] The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary shortTitle : string [0..1] An explanatory or alternate title for Display of the suggested method of how to cite this Evidence giving additional information about its content subtitle citeAs : string markdown [0..1] The status of this evidence. summary. Enables tracking the life-cycle of the content (this element modifies the meaning of other elements) status : code [1..1] « The lifecycle status of an artifact. null (Strength=Required) PublicationStatus ! » A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and no version of this resource will ever be intended for genuine usage experimental : boolean [0..1] The date (and optionally time) when the evidence summary was published. last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence summary changes date : dateTime [0..1] The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage approvalDate : date [0..1] The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date lastReviewDate : date [0..1] An individiual, organization, or device primarily involved in the creation and maintenance of the content author : ContactDetail [0..*] The name of the organization or individual that published responsible for the release and ongoing maintenance of the evidence publisher : string [0..1] Contact details to assist a user in finding and communicating with the publisher contact : ContactDetail [0..*] A free text natural language description of Who entered the data for the evidence from a consumer's perspective description recorder : markdown ContactDetail [0..1] [0..*] A human-readable string to clarify An individiual, organization, or explain concepts about device primarily responsible for internal coherence of the resource content note editor : Annotation ContactDetail [0..*] An individiual, organization, or device primarily responsible for review of some aspect of the content reviewer : ContactDetail [0..*] An individiual, organization, or device responsible for officially endorsing the content for use in some setting endorser : ContactDetail [0..*] The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances useContext : UsageContext [0..*] A legal or geographic region in which the evidence Explanation of why this Evidence is intended to be used needed and why it has been designed as it has jurisdiction purpose : CodeableConcept [0..*] « Countries and regions within which this artifact is targeted for use. (Strength=Extensible) Jurisdiction ValueSet markdown + » [0..1] A copyright statement relating to the evidence Evidence and/or its contents. Copyright statements are generally legal notices of intellectual property ownership and may include restrictions on the use and publishing of the evidence Evidence copyright : markdown [0..1] A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are restricted. (e.g. 'All rights reserved', 'Some rights reserved') copyrightLabel : string [0..1] A natural language summary of the evidence description : markdown [0..1] Declarative description of the Evidence, such as conclusion or bottom line statement assertion : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] The date on which design of the resource content was approved by synthesis (combination of studies) that produced this evidence. The design is described with any number of synthesis characteristics, such as type of meta-analysis synthesisType : CodeableConcept [0..*] « null (Strength=Example) StatisticSynthesisType ?? » The design of the publisher. Approval happens once when study that produced this evidence. The design is described with any number of study design characteristics studyDesign : CodeableConcept [0..*] « null (Strength=Extensible) StudyDesign + » RelatesTo The type of relationship to the content related artifact type : CodeableConcept [1..1] « null (Strength=Extensible) ArtifactRelationshipType + » The artifact that is officially approved for usage related to this Evidence Resource approvalDate target[x] : date DataType [1..1] « uri | Attachment | canonical ( Any )| Reference ( Any )| markdown » VariableDefinition A text description or summary of the variable description : markdown [0..1] The date on which Footnotes and/or explanatory notes note : Annotation [0..*] Classification of the resource content was last reviewed. Review happens periodically after approval but does not change role of the original approval date variable lastReviewDate variableRole : date code [1..1] « null (Strength=Required) EvidenceVariableRole ! » Sub-classification of the role of the variable roleSubtype : CodeableConcept [0..1] « null (Strength=Example) EvidenceVariableRoleSubtype ?? » The period during which reference value used for comparison comparatorCategory : string [0..1] Definition of the evidence content was or is planned actual variable related to be the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in active use the study effectivePeriod observed : Period Reference [0..1] « Group | EvidenceVariable » Descriptive topics Definition of the intended variable related to the content of Evidence, i.e., the Evidence. Topics provide a high-level categorization grouping types of Evidences that can be useful population, exposure, or outcome for filtering and searching which the statistical finding is being interpreted topic intended : Reference [0..1] « Group | EvidenceVariable » Indication of quality of match between intended variable to actual variable directnessMatch : CodeableConcept [0..*] [0..1] « High-level categorization null (Strength=Example) EvidenceDirectness ?? » Statistic A natural language summary of the definition, used for searching, sorting, statistic description : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] Type of statistic, e.g., relative risk. The statistic type is a classification that formally defines the relationship between the variables (noted in Evidence.variableDefinition) and filtering. the value specification (noted in Evidence.statistic.quantity) statisticType : CodeableConcept [0..1] « null (Strength=Example) DefinitionTopic StatisticStatisticType ?? » An individiual or organization primarily involved in When the creation measured variable (outcome) is handled categorically, the category element is used to define which category the statistic is reporting category : CodeableConcept [0..1] Statistic value quantity : Quantity [0..1] The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and maintenance sampleSize.numberOfParticipants numberOfEvents : unsignedInt [0..1] The number of participants affected where the unit of analysis is the content same as sampleSize.knownDataCount and sampleSize.numberOfParticipants author numberAffected : ContactDetail unsignedInt [0..1] SampleSize Human-readable summary of study sample size. A human-readable string to clarify or explain concepts about the sample size description : markdown [0..1] Footnote or explanatory note about the sample size note : Annotation [0..*] An individual Count of studies or organization primarily responsible samples combined to become the total sample for internal coherence the statistic numberOfStudies : unsignedInt [0..1] Count of members in the content total sample for the statistic editor numberOfParticipants : ContactDetail unsignedInt [0..*] [0..1] An individual or organization primarily responsible Number of participants with known results for review measured variables knownDataCount : unsignedInt [0..1] Total number of some aspect participants who were analayzed numberAnalyzed : unsignedInt [0..1] AttributeEstimate Human-readable summary of the content estimate reviewer description : ContactDetail markdown [0..*] [0..1] An individual Footnote or organization responsible for officially endorsing explanatory note about the content for use in some setting estimate endorser note : ContactDetail Annotation [0..*] Related artifacts such as additional documentation, justification, The type of attribute estimate, e.g., confidence interval or bibliographic references p value relatedArtifact type : RelatedArtifact CodeableConcept [0..*] [0..1] « null (Strength=Example) StatisticAttributeEstimateType ?? » A reference to a EvidenceVariable resource that defines The singular quantity of the population attribute estimate, for attribute estimates represented as single values, which may include a unit of measure quantity : Quantity [0..1] Use 0.95 for a 95% confidence interval level : decimal [0..1] Lower and upper bound values of the research attribute estimate exposureBackground range : Reference Range [0..1] ModelCharacteristic Description of a component of the method to generate the statistic code : CodeableConcept [1..1] « EvidenceVariable null (Strength=Example) StatisticModelCode ?? » A reference Further specification of the value of the component of the method to a EvidenceVariable resource that defines generate the exposure statistic value[x] : DataType [0..1] « Quantity ( SimpleQuantity )| Range | CodeableConcept » The plan for analysis intended : boolean [0..1] This model characteristic is part of the research analysis that was applied, whether or not the analysis followed the plan exposureVariant applied : boolean [0..1] Variable Description and definition of the variable variableDefinition : Reference [0..*] [1..1] « Group | EvidenceVariable » A reference to a EvidenceVariable resomece that defines How the outcome variable is classified for the research use in adjusted analysis outcome handling : Reference CodeableConcept [0..1] « null (Strength=Example) EvidenceVariableHandlingExamp... ?? » Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable valueCategory : CodeableConcept [0..*] Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable valueQuantity : Quantity [0..*] Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable valueRange : Range [0..*] Certainty Textual description of certainty description : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] Aspect of certainty being rated type : CodeableConcept [0..1] « EvidenceVariable null (Strength=Example) EvidenceCertaintyType ?? » Assessment or judgement of the aspect rating : CodeableConcept [0..1] « null (Strength=Example) StatisticCertaintyRating ?? » Individual or group who did the rating rater : string [0..*] Relationships that this Evidence has with other FHIR or non-FHIR resources that already exist relatesTo [0..*] Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about variableDefinition [0..*] Count of participants in the study sample sampleSize [0..1] A nested attribute estimate; which is the attribute estimate of an attribute estimate attributeEstimate [0..*] A statistical attribute of the statistic such as a measure of heterogeneity attributeEstimate [0..*] A variable adjusted for in the adjusted analysis variable [0..*] An attribute of the model characteristic attribute [0..*] A component of the method to generate the statistic modelCharacteristic [0..*] Values and parameters for a single statistic statistic [0..*] A domain or subdomain of certainty subcomponent [0..*] Assessment of certainty, confidence in the estimates, or quality of the evidence certainty [0..*]

XML Template 

<

<Evidence xmlns="http://hl7.org/fhir"> doco

 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <
 <</identifier>
 <
 <
 <
 <
 <
 <
 <
 <

 <url value="[uri]"/><!-- 0..1 Canonical identifier for this evidence, represented as a globally unique URI -->
 <identifier><!-- 0..* Identifier Additional identifier for the summary --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of this summary -->
 <versionAlgorithm[x]><!-- 0..1 string|Coding How to compare versions --></versionAlgorithm[x]>
 <name value="[string]"/><!-- I 0..1 Name for this summary (machine friendly) -->
 <title value="[string]"/><!-- 0..1 Name for this summary (human friendly) -->
 <citeAs value="[markdown]"/><!-- 0..1 Display of how to cite this Evidence -->
 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <experimental value="[boolean]"/><!-- 0..1 For testing only - never for real usage -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <approvalDate value="[date]"/><!-- 0..1 When the summary was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the summary was last reviewed by the publisher -->
 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <publisher value="[string]"/><!-- 0..1 Name of the publisher/steward (organization or individual) -->

 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <
 <</note>

 <recorder><!-- 0..* ContactDetail Who entered the data for the evidence --></recorder>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>

 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <</jurisdiction>
 <
 <
 <
 <</effectivePeriod>
 <</topic>
 <</author>
 <</editor>
 <</reviewer>
 <</endorser>
 <</relatedArtifact>
 <</exposureBackground>
 <</exposureVariant>
 <</outcome>

 <purpose value="[markdown]"/><!-- 0..1 Why this Evidence is defined -->
 <copyright value="[markdown]"/><!-- 0..1 Intellectual property ownership, may include restrictions on use -->
 <copyrightLabel value="[string]"/><!-- 0..1 Copyright holder and year(s) -->
 <relatesTo>  <!-- 0..* Relationships to other Resources -->
  <type><!-- 1..1 CodeableConcept documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes icon --></type>
  <target[x]><!-- 1..1 uri|Attachment|canonical(Any)|Reference(Any)|markdown The artifact that is related to this Evidence --></target[x]>
 </relatesTo>
 <description value="[markdown]"/><!-- 0..1 Description of the particular summary -->
 <assertion value="[markdown]"/><!-- 0..1 Declarative description of the Evidence -->
 <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
 <variableDefinition>  <!-- 0..* Description, classification, and definition of a single variable -->
  <description value="[markdown]"/><!-- 0..1 A text description or summary of the variable -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <variableRole value="[code]"/><!-- 1..1 population | exposure | outcome | covariate -->
  <roleSubtype><!-- 0..1 CodeableConcept Sub-classification of the role of the variable icon --></roleSubtype>
  <comparatorCategory value="[string]"/><!-- 0..1 The reference value used for comparison -->
  <observed><!-- 0..1 Reference(EvidenceVariable|Group) Definition of the actual variable related to the statistic(s) --></observed>
  <intended><!-- 0..1 Reference(EvidenceVariable|Group) Definition of the intended variable related to the Evidence --></intended>
  <directnessMatch><!-- 0..1 CodeableConcept low | moderate | high | exact icon --></directnessMatch>
 </variableDefinition>
 <synthesisType><!-- 0..* CodeableConcept The design of the synthesis (combination of studies) that produced this evidence icon --></synthesisType>
 <studyDesign><!-- 0..* CodeableConcept The design of the study that produced this evidence --></studyDesign>
 <statistic>  <!-- 0..* Values and parameters for a single statistic -->
  <description value="[markdown]"/><!-- 0..1 A natural language summary of the statistic -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <statisticType><!-- 0..1 CodeableConcept Type of statistic, e.g., relative risk icon --></statisticType>
  <category><!-- 0..1 CodeableConcept Associated category for categorical variable --></category>
  <quantity><!-- 0..1 Quantity Statistic value --></quantity>
  <numberOfEvents value="[unsignedInt]"/><!-- 0..1 The number of events associated with the statistic -->
  <numberAffected value="[unsignedInt]"/><!-- 0..1 The number of participants affected -->
  <sampleSize>  <!-- 0..1 Count of participants in the study sample -->
   <description value="[markdown]"/><!-- 0..1 Textual description of sample size for statistic -->
   <note><!-- 0..* Annotation Footnote or explanatory note about the sample size --></note>
   <numberOfStudies value="[unsignedInt]"/><!-- 0..1 Number of contributing studies -->
   <numberOfParticipants value="[unsignedInt]"/><!-- 0..1 Total number of participants -->
   <knownDataCount value="[unsignedInt]"/><!-- 0..1 Number of participants with known results for measured variables -->
   <numberAnalyzed value="[unsignedInt]"/><!-- 0..1 Total number of participants who were analayzed -->
  </sampleSize>
  <attributeEstimate>  <!-- 0..* An attribute of the Statistic -->
   <description value="[markdown]"/><!-- 0..1 Textual description of the attribute estimate -->
   <note><!-- 0..* Annotation Footnote or explanatory note about the estimate --></note>
   <type><!-- 0..1 CodeableConcept The type of attribute estimate, e.g., confidence interval or p value icon --></type>
   <quantity><!-- 0..1 Quantity The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure --></quantity>
   <level value="[decimal]"/><!-- 0..1 Level of confidence interval, e.g., 0.95 for 95% confidence interval -->
   <range><!-- 0..1 Range Lower and upper bound values of the attribute estimate --></range>
   <attributeEstimate><!-- 0..* Content as for Evidence.statistic.attributeEstimate A nested attribute estimate; which is the attribute estimate of an attribute estimate --></attributeEstimate>
  </attributeEstimate>
  <modelCharacteristic>  <!-- 0..* An aspect of the statistical model -->
   <code><!-- 1..1 CodeableConcept Model specification icon --></code>
   <value[x]><!-- 0..1 Quantity(SimpleQuantity)|Range|CodeableConcept The specific value (when paired with code) --></value[x]>
   <intended value="[boolean]"/><!-- 0..1 The plan for analysis -->
   <applied value="[boolean]"/><!-- 0..1 This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan -->
   <variable>  <!-- 0..* A variable adjusted for in the adjusted analysis -->
    <variableDefinition><!-- 1..1 Reference(EvidenceVariable|Group) Description and definition of the variable --></variableDefinition>
    <handling><!-- 0..1 CodeableConcept boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified --></handling>
    <valueCategory><!-- 0..* CodeableConcept Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueCategory>
    <valueQuantity><!-- 0..* Quantity Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueQuantity>
    <valueRange><!-- 0..* Range Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueRange>
   </variable>
   <attribute><!-- 0..* Content as for Evidence.statistic.attributeEstimate An attribute of the model characteristic --></attribute>
  </modelCharacteristic>
 </statistic>
 <certainty>  <!-- 0..* Certainty or quality of the evidence -->
  <description value="[markdown]"/><!-- 0..1 Textual description of certainty -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <type><!-- 0..1 CodeableConcept Aspect of certainty being rated icon --></type>
  <rating><!-- 0..1 CodeableConcept Assessment or judgement of the aspect icon --></rating>
  <rater value="[string]"/><!-- 0..* Individual or group who did the rating -->
  <subcomponent><!-- 0..* Content as for Evidence.certainty A domain or subdomain of certainty --></subcomponent>
 </certainty>

</Evidence>

JSON Template 

{doco
  "resourceType" : "",

  "resourceType" : "Evidence",

  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "

  "url" : "<uri>", // Canonical identifier for this evidence, represented as a globally unique URI
  "identifier" : [{ Identifier }], // Additional identifier for the summary
  "version" : "<string>", // Business version of this summary
  // versionAlgorithm[x]: How to compare versions. One of these 2:

  "versionAlgorithmString" : "<string>",
  "versionAlgorithmCoding" : { Coding },
  "name" : "<string>", // I Name for this summary (machine friendly)
  "title" : "<string>", // Name for this summary (human friendly)
  "citeAs" : "<markdown>", // Display of how to cite this Evidence
  "status" : "<code>", // R!  draft | active | retired | unknown
  "experimental" : <boolean>, // For testing only - never for real usage
  "date" : "<dateTime>", // Date last changed
  "approvalDate" : "<date>", // When the summary was approved by publisher
  "lastReviewDate" : "<date>", // When the summary was last reviewed by the publisher
  "author" : [{ ContactDetail }], // Who authored the content
  "publisher" : "<string>", // Name of the publisher/steward (organization or individual)

  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "
  "

  "recorder" : [{ ContactDetail }], // Who entered the data for the evidence
  "editor" : [{ ContactDetail }], // Who edited the content
  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content

  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "

  "purpose" : "<markdown>", // Why this Evidence is defined
  "copyright" : "<markdown>", // Intellectual property ownership, may include restrictions on use
  "copyrightLabel" : "<string>", // Copyright holder and year(s)
  "relatesTo" : [{ // Relationships to other Resources
    "type" : { CodeableConcept }, // R!  documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes icon
    // target[x]: The artifact that is related to this Evidence. One of these 5:

    "targetUri" : "<uri>",
    "targetAttachment" : { Attachment },
    "targetCanonical" : "<canonical(Any)>",
    "targetReference" : { Reference(Any) },
    "targetMarkdown" : "<markdown>"
  }],
  "description" : "<markdown>", // Description of the particular summary
  "assertion" : "<markdown>", // Declarative description of the Evidence
  "note" : [{ Annotation }], // Footnotes and/or explanatory notes
  "variableDefinition" : [{ // Description, classification, and definition of a single variable
    "description" : "<markdown>", // A text description or summary of the variable
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "variableRole" : "<code>", // R!  population | exposure | outcome | covariate
    "roleSubtype" : { CodeableConcept }, // Sub-classification of the role of the variable icon
    "comparatorCategory" : "<string>", // The reference value used for comparison
    "observed" : { Reference(EvidenceVariable|Group) }, // Definition of the actual variable related to the statistic(s)
    "intended" : { Reference(EvidenceVariable|Group) }, // Definition of the intended variable related to the Evidence
    "directnessMatch" : { CodeableConcept } // low | moderate | high | exact icon
  }],
  "synthesisType" : [{ CodeableConcept }], // The design of the synthesis (combination of studies) that produced this evidence icon
  "studyDesign" : [{ CodeableConcept }], // The design of the study that produced this evidence
  "statistic" : [{ // Values and parameters for a single statistic
    "description" : "<markdown>", // A natural language summary of the statistic
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "statisticType" : { CodeableConcept }, // Type of statistic, e.g., relative risk icon
    "category" : { CodeableConcept }, // Associated category for categorical variable
    "quantity" : { Quantity }, // Statistic value
    "numberOfEvents" : "<unsignedInt>", // The number of events associated with the statistic
    "numberAffected" : "<unsignedInt>", // The number of participants affected
    "sampleSize" : { // Count of participants in the study sample
      "description" : "<markdown>", // Textual description of sample size for statistic
      "note" : [{ Annotation }], // Footnote or explanatory note about the sample size
      "numberOfStudies" : "<unsignedInt>", // Number of contributing studies
      "numberOfParticipants" : "<unsignedInt>", // Total number of participants
      "knownDataCount" : "<unsignedInt>", // Number of participants with known results for measured variables
      "numberAnalyzed" : "<unsignedInt>" // Total number of participants who were analayzed
    },
    "attributeEstimate" : [{ // An attribute of the Statistic
      "description" : "<markdown>", // Textual description of the attribute estimate
      "note" : [{ Annotation }], // Footnote or explanatory note about the estimate
      "type" : { CodeableConcept }, // The type of attribute estimate, e.g., confidence interval or p value icon
      "quantity" : { Quantity }, // The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
      "level" : <decimal>, // Level of confidence interval, e.g., 0.95 for 95% confidence interval
      "range" : { Range }, // Lower and upper bound values of the attribute estimate
      "attributeEstimate" : [{ Content as for Evidence.statistic.attributeEstimate }] // A nested attribute estimate; which is the attribute estimate of an attribute estimate
    }],
    "modelCharacteristic" : [{ // An aspect of the statistical model
      "code" : { CodeableConcept }, // R!  Model specification icon
      // value[x]: The specific value (when paired with code). One of these 3:

      "valueQuantity" : { Quantity(SimpleQuantity) },
      "valueRange" : { Range },
      "valueCodeableConcept" : { CodeableConcept },
      "intended" : <boolean>, // The plan for analysis
      "applied" : <boolean>, // This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
      "variable" : [{ // A variable adjusted for in the adjusted analysis
        "variableDefinition" : { Reference(EvidenceVariable|Group) }, // R!  Description and definition of the variable
        "handling" : { CodeableConcept }, // boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
        "valueCategory" : [{ CodeableConcept }], // Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        "valueQuantity" : [{ Quantity }], // Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        "valueRange" : [{ Range }] // Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
      }],
      "attribute" : [{ Content as for Evidence.statistic.attributeEstimate }] // An attribute of the model characteristic
    }]
  }],
  "certainty" : [{ // Certainty or quality of the evidence
    "description" : "<markdown>", // Textual description of certainty
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "type" : { CodeableConcept }, // Aspect of certainty being rated icon
    "rating" : { CodeableConcept }, // Assessment or judgement of the aspect icon
    "rater" : ["<string>"], // Individual or group who did the rating
    "subcomponent" : [{ Content as for Evidence.certainty }] // A domain or subdomain of certainty
  }]

}

Turtle Template 

@prefix fhir: <http://hl7.org/fhir/> .doco


[ a fhir:;

[ a fhir:Evidence;

  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from 
  # from 
  fhir:
  fhir:
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  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
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  fhir:
  fhir:
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  fhir:
  fhir:
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  fhir:

  # from Resource: fhir:id, fhir:meta, fhir:implicitRules, and fhir:language
  # from DomainResource: fhir:text, fhir:contained, fhir:extension, and fhir:modifierExtension
  fhir:url [ uri ] ; # 0..1 Canonical identifier for this evidence, represented as a globally unique URI
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Additional identifier for the summary
  fhir:version [ string ] ; # 0..1 Business version of this summary
  # versionAlgorithm[x] : 0..1 How to compare versions. One of these 2
    fhir:versionAlgorithm [  a fhir:String ; string ]
    fhir:versionAlgorithm [  a fhir:Coding ; Coding ]
  fhir:name [ string ] ; # 0..1 I Name for this summary (machine friendly)
  fhir:title [ string ] ; # 0..1 Name for this summary (human friendly)
  fhir:citeAs [ markdown ] ; # 0..1 Display of how to cite this Evidence
  fhir:status [ code ] ; # 1..1 draft | active | retired | unknown
  fhir:experimental [ boolean ] ; # 0..1 For testing only - never for real usage
  fhir:date [ dateTime ] ; # 0..1 Date last changed
  fhir:approvalDate [ date ] ; # 0..1 When the summary was approved by publisher
  fhir:lastReviewDate [ date ] ; # 0..1 When the summary was last reviewed by the publisher
  fhir:author  ( [ ContactDetail ] ... ) ; # 0..* Who authored the content
  fhir:publisher [ string ] ; # 0..1 Name of the publisher/steward (organization or individual)
  fhir:contact  ( [ ContactDetail ] ... ) ; # 0..* Contact details for the publisher
  fhir:recorder  ( [ ContactDetail ] ... ) ; # 0..* Who entered the data for the evidence
  fhir:editor  ( [ ContactDetail ] ... ) ; # 0..* Who edited the content
  fhir:reviewer  ( [ ContactDetail ] ... ) ; # 0..* Who reviewed the content
  fhir:endorser  ( [ ContactDetail ] ... ) ; # 0..* Who endorsed the content
  fhir:useContext  ( [ UsageContext ] ... ) ; # 0..* The context that the content is intended to support
  fhir:purpose [ markdown ] ; # 0..1 Why this Evidence is defined
  fhir:copyright [ markdown ] ; # 0..1 Intellectual property ownership, may include restrictions on use
  fhir:copyrightLabel [ string ] ; # 0..1 Copyright holder and year(s)
  fhir:relatesTo ( [ # 0..* Relationships to other Resources
    fhir:type [ CodeableConcept ] ; # 1..1 documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes
    # target[x] : 1..1 The artifact that is related to this Evidence. One of these 5
      fhir:target [  a fhir:Uri ; uri ]
      fhir:target [  a fhir:Attachment ; Attachment ]
      fhir:target [  a fhir:Canonical ; canonical(Any) ]
      fhir:target [  a fhir:Reference ; Reference(Any) ]
      fhir:target [  a fhir:Markdown ; markdown ]
  ] ... ) ;
  fhir:description [ markdown ] ; # 0..1 Description of the particular summary
  fhir:assertion [ markdown ] ; # 0..1 Declarative description of the Evidence
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
  fhir:variableDefinition ( [ # 0..* Description, classification, and definition of a single variable
    fhir:description [ markdown ] ; # 0..1 A text description or summary of the variable
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:variableRole [ code ] ; # 1..1 population | exposure | outcome | covariate
    fhir:roleSubtype [ CodeableConcept ] ; # 0..1 Sub-classification of the role of the variable
    fhir:comparatorCategory [ string ] ; # 0..1 The reference value used for comparison
    fhir:observed [ Reference(EvidenceVariable|Group) ] ; # 0..1 Definition of the actual variable related to the statistic(s)
    fhir:intended [ Reference(EvidenceVariable|Group) ] ; # 0..1 Definition of the intended variable related to the Evidence
    fhir:directnessMatch [ CodeableConcept ] ; # 0..1 low | moderate | high | exact
  ] ... ) ;
  fhir:synthesisType  ( [ CodeableConcept ] ... ) ; # 0..* The design of the synthesis (combination of studies) that produced this evidence
  fhir:studyDesign  ( [ CodeableConcept ] ... ) ; # 0..* The design of the study that produced this evidence
  fhir:statistic ( [ # 0..* Values and parameters for a single statistic
    fhir:description [ markdown ] ; # 0..1 A natural language summary of the statistic
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:statisticType [ CodeableConcept ] ; # 0..1 Type of statistic, e.g., relative risk
    fhir:category [ CodeableConcept ] ; # 0..1 Associated category for categorical variable
    fhir:quantity [ Quantity ] ; # 0..1 Statistic value
    fhir:numberOfEvents [ unsignedInt ] ; # 0..1 The number of events associated with the statistic
    fhir:numberAffected [ unsignedInt ] ; # 0..1 The number of participants affected
    fhir:sampleSize [ # 0..1 Count of participants in the study sample
      fhir:description [ markdown ] ; # 0..1 Textual description of sample size for statistic
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnote or explanatory note about the sample size
      fhir:numberOfStudies [ unsignedInt ] ; # 0..1 Number of contributing studies
      fhir:numberOfParticipants [ unsignedInt ] ; # 0..1 Total number of participants
      fhir:knownDataCount [ unsignedInt ] ; # 0..1 Number of participants with known results for measured variables
      fhir:numberAnalyzed [ unsignedInt ] ; # 0..1 Total number of participants who were analayzed
    ] ;
    fhir:attributeEstimate ( [ # 0..* An attribute of the Statistic
      fhir:description [ markdown ] ; # 0..1 Textual description of the attribute estimate
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnote or explanatory note about the estimate
      fhir:type [ CodeableConcept ] ; # 0..1 The type of attribute estimate, e.g., confidence interval or p value
      fhir:quantity [ Quantity ] ; # 0..1 The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
      fhir:level [ decimal ] ; # 0..1 Level of confidence interval, e.g., 0.95 for 95% confidence interval
      fhir:range [ Range ] ; # 0..1 Lower and upper bound values of the attribute estimate
      fhir:attributeEstimate  ( [ See Evidence.statistic.attributeEstimate ] ... ) ; # 0..* A nested attribute estimate; which is the attribute estimate of an attribute estimate
    ] ... ) ;
    fhir:modelCharacteristic ( [ # 0..* An aspect of the statistical model
      fhir:code [ CodeableConcept ] ; # 1..1 Model specification
      # value[x] : 0..1 The specific value (when paired with code). One of these 3
        fhir:value [  a fhir:SimpleQuantity ; Quantity(SimpleQuantity) ]
        fhir:value [  a fhir:Range ; Range ]
        fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:intended [ boolean ] ; # 0..1 The plan for analysis
      fhir:applied [ boolean ] ; # 0..1 This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
      fhir:variable ( [ # 0..* A variable adjusted for in the adjusted analysis
        fhir:variableDefinition [ Reference(EvidenceVariable|Group) ] ; # 1..1 Description and definition of the variable
        fhir:handling [ CodeableConcept ] ; # 0..1 boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
        fhir:valueCategory  ( [ CodeableConcept ] ... ) ; # 0..* Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        fhir:valueQuantity  ( [ Quantity ] ... ) ; # 0..* Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        fhir:valueRange  ( [ Range ] ... ) ; # 0..* Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
      ] ... ) ;
      fhir:attribute  ( [ See Evidence.statistic.attributeEstimate ] ... ) ; # 0..* An attribute of the model characteristic
    ] ... ) ;
  ] ... ) ;
  fhir:certainty ( [ # 0..* Certainty or quality of the evidence
    fhir:description [ markdown ] ; # 0..1 Textual description of certainty
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:type [ CodeableConcept ] ; # 0..1 Aspect of certainty being rated
    fhir:rating [ CodeableConcept ] ; # 0..1 Assessment or judgement of the aspect
    fhir:rater  ( [ string ] ... ) ; # 0..* Individual or group who did the rating
    fhir:subcomponent  ( [ See Evidence.certainty ] ... ) ; # 0..* A domain or subdomain of certainty
  ] ... ) ;

]

Changes since R3 from R5 to R6

Evidence
Evidence.citeAs
  • Renamed from citeAs[x] to citeAs
  • Remove Type Reference(Citation)
Evidence.recorder
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.variableDefinition
  • Min Cardinality changed from 1 to 0
Evidence.variableDefinition.variableRole
  • Type changed from CodeableConcept to code
  • Change binding strength from extensible to required
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Remove Binding `http://terminology.hl7.org/ValueSet/directness` (extensible)
Evidence.synthesisType
  • Max Cardinality changed from 1 to *
  • Remove Binding `http://terminology.hl7.org/ValueSet/synthesis-type` (extensible)
Evidence.studyDesign
  • Change code system for extensibly bound codes from "http://hl7.org/fhir/study-design" to "https://fevir.net/sevco"
Evidence.statistic.statisticType
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-type` (extensible)
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/attribute-estimate-type` (extensible)
Evidence.statistic.modelCharacteristic.code
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-model-code` (extensible)
Evidence.statistic.modelCharacteristic.value[x]
  • Renamed from value to value[x]
  • Add Types Range, CodeableConcept
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Type changed from code to CodeableConcept
  • Remove Binding `http://hl7.org/fhir/ValueSet/variable-handling|5.0.0` (required)
Evidence.statistic.modelCharacteristic.attribute
  • Renamed from attributeEstimate to attribute
Evidence.certainty.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-type` (extensible)
Evidence.certainty.rating
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-rating` (extensible)
Evidence.certainty.rater
  • Max Cardinality changed from 1 to *
Evidence.relatedArtifact
  • Deleted

This resource did not exist in Release 2 Changes from R4B to R6

Evidence
Evidence.versionAlgorithm[x]
  • Added Element
Evidence.name
  • Added Element
Evidence.citeAs
  • Renamed from citeAs[x] to citeAs
  • Remove Type Reference(Citation)
Evidence.experimental
  • Added Element
Evidence.recorder
  • Added Element
Evidence.purpose
  • Added Element
Evidence.copyright
  • Added Element
Evidence.copyrightLabel
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.variableDefinition
  • Min Cardinality changed from 1 to 0
Evidence.variableDefinition.variableRole
  • Type changed from CodeableConcept to code
  • Change binding strength from extensible to required
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Remove Binding `http://hl7.org/fhir/ValueSet/directness` (extensible)
Evidence.synthesisType
  • Max Cardinality changed from 1 to *
  • Remove Binding `http://hl7.org/fhir/ValueSet/synthesis-type` (extensible)
Evidence.studyDesign
  • Added Element
Evidence.statistic.description
  • Type changed from string to markdown
Evidence.statistic.statisticType
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-type` (extensible)
Evidence.statistic.sampleSize.description
  • Type changed from string to markdown
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate.description
  • Type changed from string to markdown
Evidence.statistic.attributeEstimate.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/attribute-estimate-type` (extensible)
Evidence.statistic.modelCharacteristic.code
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-model-code` (extensible)
Evidence.statistic.modelCharacteristic.value[x]
  • Renamed from value to value[x]
  • Add Types Range, CodeableConcept
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Type changed from code to CodeableConcept
  • Remove Binding `http://hl7.org/fhir/ValueSet/variable-handling|4.3.0` (required)
Evidence.statistic.modelCharacteristic.attribute
  • Added Element
Evidence.certainty.description
  • Type changed from string to markdown
Evidence.certainty.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-type` (extensible)
Evidence.certainty.rating
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-rating` (extensible)
Evidence.certainty.rater
  • Max Cardinality changed from 1 to *
Evidence.relatedArtifact
  • Deleted
Evidence.studyType
  • Deleted
Evidence.statistic.modelCharacteristic.attributeEstimate
  • Deleted

Changes from R4 to R6

Evidence
Evidence.versionAlgorithm[x]
  • Added Element
Evidence.citeAs
  • Added Element
Evidence.experimental
  • Added Element
Evidence.recorder
  • Added Element
Evidence.purpose
  • Added Element
Evidence.copyrightLabel
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.assertion
  • Added Element
Evidence.variableDefinition
  • Added Element
Evidence.variableDefinition.description
  • Added Element
Evidence.variableDefinition.note
  • Added Element
Evidence.variableDefinition.variableRole
  • Added Mandatory Element
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.observed
  • Added Element
Evidence.variableDefinition.intended
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Added Element
Evidence.synthesisType
  • Added Element
Evidence.studyDesign
  • Added Element
Evidence.statistic
  • Added Element
Evidence.statistic.description
  • Added Element
Evidence.statistic.note
  • Added Element
Evidence.statistic.statisticType
  • Added Element
Evidence.statistic.category
  • Added Element
Evidence.statistic.quantity
  • Added Element
Evidence.statistic.numberOfEvents
  • Added Element
Evidence.statistic.numberAffected
  • Added Element
Evidence.statistic.sampleSize
  • Added Element
Evidence.statistic.sampleSize.description
  • Added Element
Evidence.statistic.sampleSize.note
  • Added Element
Evidence.statistic.sampleSize.numberOfStudies
  • Added Element
Evidence.statistic.sampleSize.numberOfParticipants
  • Added Element
Evidence.statistic.sampleSize.knownDataCount
  • Added Element
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate
  • Added Element
Evidence.statistic.attributeEstimate.description
  • Added Element
Evidence.statistic.attributeEstimate.note
  • Added Element
Evidence.statistic.attributeEstimate.type
  • Added Element
Evidence.statistic.attributeEstimate.quantity
  • Added Element
Evidence.statistic.attributeEstimate.level
  • Added Element
Evidence.statistic.attributeEstimate.range
  • Added Element
Evidence.statistic.attributeEstimate.attributeEstimate
  • Added Element
Evidence.statistic.modelCharacteristic
  • Added Element
Evidence.statistic.modelCharacteristic.code
  • Added Mandatory Element
Evidence.statistic.modelCharacteristic.value[x]
  • Added Element
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable
  • Added Element
Evidence.statistic.modelCharacteristic.variable.variableDefinition
  • Added Mandatory Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueCategory
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueQuantity
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueRange
  • Added Element
Evidence.statistic.modelCharacteristic.attribute
  • Added Element
Evidence.certainty
  • Added Element
Evidence.certainty.description
  • Added Element
Evidence.certainty.note
  • Added Element
Evidence.certainty.type
  • Added Element
Evidence.certainty.rating
  • Added Element
Evidence.certainty.rater
  • Added Element
Evidence.certainty.subcomponent
  • Added Element
Evidence.shortTitle
  • Deleted
Evidence.subtitle
  • Deleted
Evidence.jurisdiction
  • Deleted
Evidence.effectivePeriod
  • Deleted
Evidence.topic
  • Deleted
Evidence.relatedArtifact
  • Deleted
Evidence.exposureBackground
  • Deleted
Evidence.exposureVariant
  • Deleted
Evidence.outcome
  • Deleted

See the Full Difference for further information

This analysis is available for R4 as XML or JSON and for R4B as XML or JSON .

Structure

A research context or question 0..1 Title Subordinate title markdown Annotation Intended jurisdiction for evidence (if applicable) date When ContactDetail ContactDetail RelatedArtifact What population? Σ What outcome?
Name Flags Card. Type Description & Constraints      Filter: Filters doco
. . Evidence I TU N DomainResource Single evidence bit
+ Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation

Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension
Interfaces Implemented: MetadataResource
. . . url Σ C 0..1 uri Canonical identifier for this evidence, represented as a globally unique URI (globally unique)
+ Warning: URL should not contain | or # - these characters make processing canonical references problematic
. . . identifier Σ 0..* Identifier Additional identifier for the evidence summary

. . . version Σ 0..1 string Business version of the evidence this summary
. . name . versionAlgorithm[x] Σ I 0..1 How to compare versions
Binding: Version Algorithm ( Extensible )
. . . . versionAlgorithmString string Name for this evidence (computer friendly)
. . . . versionAlgorithmCoding Coding
. . . title name Σ C 0..1 string Name for this evidence (human summary (machine friendly)
. . . shortTitle title Σ T 0..1 string Name for use in informal contexts this summary (human friendly)
. . . subtitle citeAs 0..1 string markdown Display of the how to cite this Evidence
. . . status ?! Σ 1..1 code draft | active | retired | unknown
Binding: PublicationStatus ( Required )
. . . date experimental 0..1 Σ boolean For testing only - never for real usage
0..1
. . . date Σ 0..1 dateTime Date last changed
. . . approvalDate 0..1 date When the summary was approved by publisher
. . . lastReviewDate 0..1 date When the summary was last reviewed by the publisher
... author Σ 0..* ContactDetail Who authored the content

0..1
. . . publisher Σ T 0..1 string Name of the publisher publisher/steward (organization or individual)
. . . contact Σ 0..* ContactDetail Contact details for the publisher

. . description . recorder 0..* Σ ContactDetail Who entered the data for the evidence

0..1
. . . editor Natural language description of 0..* ContactDetail Who edited the evidence content

. . note . reviewer 0..* ContactDetail Who reviewed the content

0..*
. . . endorser 0..* ContactDetail Who endorsed the content
Used for footnotes or explanatory notes
. . . useContext Σ 0..* UsageContext The context that the content is intended to support

. . jurisdiction . purpose 0..1 Σ markdown Why this Evidence is defined
. . . copyright 0..1 markdown Intellectual property ownership, may include restrictions on use
... copyrightLabel T 0..1 string Copyright holder and year(s)
... relatesTo 0..* BackboneElement Relationships to other Resources

.... type 1..1 CodeableConcept documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes
Binding: Artifact Relationship Type icon Jurisdiction ( Extensible )
. . . . target[x] 1..1 The artifact that is related to this Evidence
. . . . copyright . targetUri uri
. . . . . targetAttachment Attachment
. . . . . targetCanonical 0..1 canonical ( Any )
..... targetReference Reference ( Any )
..... targetMarkdown markdown Use and/or publishing restrictions
. . approvalDate . description Σ T 0..1 markdown date Description of the particular summary
... assertion When T 0..1 markdown Declarative description of the evidence was approved by publisher Evidence
. . lastReviewDate . note 0..* Annotation Footnotes and/or explanatory notes

0..1
. . . variableDefinition When 0..* BackboneElement Description, classification, and definition of a single variable

.... description 0..1 markdown A text description or summary of the evidence was last reviewed variable
. . . . effectivePeriod note 0..* Annotation Footnotes and/or explanatory notes

.... variableRole Σ 1..1 code population | exposure | outcome | covariate
Binding: Evidence Variable Role ( Required )
.... roleSubtype 0..1 CodeableConcept Period Sub-classification of the role of the variable
Binding: EvidenceVariableRoleSubtype icon ( Example )
. . . . comparatorCategory 0..1 string The reference value used for comparison
.... observed Σ 0..1 Reference ( Group | EvidenceVariable ) Definition of the evidence is expected actual variable related to be used the statistic(s)
. . . topic . intended 0..1 Reference ( Group | EvidenceVariable ) Definition of the intended variable related to the Evidence
0..*
. . . . directnessMatch 0..1 CodeableConcept low | moderate | high | exact
Binding: EvidenceDirectness icon ( Example )
... synthesisType 0..* CodeableConcept The category design of the Evidence, such as Education, Treatment, Assessment, etc. synthesis (combination of studies) that produced this evidence
Binding: StatisticSynthesisType icon DefinitionTopic ( Example )

. . . author studyDesign 0..* CodeableConcept The design of the study that produced this evidence
Binding: Study Design ( Extensible )

. . . statistic 0..* BackboneElement ContactDetail Values and parameters for a single statistic

.... description Who authored 0..1 markdown A natural language summary of the content statistic
. . . . editor note 0..* Annotation Footnotes and/or explanatory notes

0..*
. . . . statisticType Who edited the content Σ 0..1 CodeableConcept Type of statistic, e.g., relative risk
Binding: StatisticStatisticType icon ( Example )
. . . . category 0..1 CodeableConcept Associated category for categorical variable
. . . . reviewer quantity Σ 0..1 Quantity Statistic value
0..*
. . . . numberOfEvents Who reviewed 0..1 unsignedInt The number of events associated with the content statistic
. . . . numberAffected 0..1 unsignedInt The number of participants affected
.... sampleSize 0..1 BackboneElement Count of participants in the study sample
..... description 0..1 markdown Textual description of sample size for statistic
. . . . . endorser note 0..* Annotation Footnote or explanatory note about the sample size

. . . . . numberOfStudies 0..1 unsignedInt Number of contributing studies
..... numberOfParticipants 0..1 unsignedInt Total number of participants
..... knownDataCount 0..1 unsignedInt Number of participants with known results for measured variables
..... numberAnalyzed 0..1 unsignedInt Total number of participants who were analayzed
.... attributeEstimate 0..* BackboneElement ContactDetail An attribute of the Statistic

..... description Who endorsed 0..1 markdown Textual description of the content attribute estimate
. . . . . relatedArtifact note 0..* Annotation Footnote or explanatory note about the estimate

0..*
. . . . . type Additional documentation, citations, etc. 0..1 CodeableConcept The type of attribute estimate, e.g., confidence interval or p value
Binding: StatisticAttributeEstimateType icon ( Example )
. . . . exposureBackground . quantity 0..1 Σ Quantity The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
..... level 0..1 decimal Level of confidence interval, e.g., 0.95 for 95% confidence interval
..... range 0..1 Range Lower and upper bound values of the attribute estimate
..... attributeEstimate 0..* see attributeEstimate A nested attribute estimate; which is the attribute estimate of an attribute estimate

.... modelCharacteristic 0..* BackboneElement An aspect of the statistical model

..... code 1..1 CodeableConcept Model specification
Binding: Statistic Model Code icon Reference ( EvidenceVariable Example )
. . . . . value[x] 0..1 The specific value (when paired with code)
. . . . . exposureVariant . valueQuantity SimpleQuantity
. . . . . . valueRange Range
. . . . . . valueCodeableConcept CodeableConcept
. . . . . intended 0..1 boolean The plan for analysis
..... applied 0..1 boolean This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
..... variable 0..* BackboneElement A variable adjusted for in the adjusted analysis

...... variableDefinition 1..1 Reference ( Group | EvidenceVariable ) Description and definition of the variable
What exposure?
. . . . . . handling 0..1 CodeableConcept boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
Binding: Evidence Variable Handling Example ( Example )
. . . . . . valueCategory 0..* CodeableConcept Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable

. . . . . . valueQuantity 0..* Quantity Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable

.... . outcome . valueRange 0..* Σ Range Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable

. . . . . attribute 0..* see attributeEstimate An attribute of the model characteristic

... certainty 0..* BackboneElement Certainty or quality of the evidence

.... description 0..1 markdown Textual description of certainty
.... note 0..* Annotation Footnotes and/or explanatory notes

.... type 0..1 CodeableConcept Aspect of certainty being rated
Binding: Evidence Certainty Type icon Reference ( EvidenceVariable Example )
. . . . rating 0..1 CodeableConcept Assessment or judgement of the aspect
Binding: StatisticCertaintyRating icon ( Example )
. . . . rater 0..* string Individual or group who did the rating

.... subcomponent 0..* see certainty A domain or subdomain of certainty


doco Documentation for this format icon

See the Extensions for this resource

UML Diagram ( Legend )

Evidence ( DomainResource ) + MetadataResource An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this evidence summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the evidence summary is stored on different servers url : uri [0..1] A formal identifier that is used to identify this evidence summary when it is represented in other formats, or referenced in a specification, model, design or an instance identifier : Identifier [0..*] The identifier that is used to identify this version of the evidence summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the evidence summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. To provide a sequence version consistent with the Decision Support Service specification, use : string [0..1] Indicates the format Major.Minor.Revision (e.g. 1.0.0). For more information on versioning knowledge assets, refer mechanism used to the Decision Support Service specification. Note that a version compare versions to determine which is required for non-experimental active artifacts more current version versionAlgorithm[x] : string DataType [0..1] « string | Coding ; null (Strength=Extensible) VersionAlgorithm + » A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation name : string [0..1] « This element has or is affected by some invariants C » A short, descriptive, user-friendly title for the evidence summary title : string [0..1] The short title provides an alternate title for use in informal descriptive contexts where the full, formal title is not necessary shortTitle : string [0..1] An explanatory or alternate title for Display of the suggested method of how to cite this Evidence giving additional information about its content subtitle citeAs : string markdown [0..1] The status of this evidence. summary. Enables tracking the life-cycle of the content (this element modifies the meaning of other elements) status : code [1..1] « The lifecycle status of an artifact. null (Strength=Required) PublicationStatus ! » A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and no version of this resource will ever be intended for genuine usage experimental : boolean [0..1] The date (and optionally time) when the evidence summary was published. last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the evidence summary changes date : dateTime [0..1] The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage approvalDate : date [0..1] The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date lastReviewDate : date [0..1] An individiual, organization, or device primarily involved in the creation and maintenance of the content author : ContactDetail [0..*] The name of the organization or individual that published responsible for the release and ongoing maintenance of the evidence publisher : string [0..1] Contact details to assist a user in finding and communicating with the publisher contact : ContactDetail [0..*] A free text natural language description of Who entered the data for the evidence from a consumer's perspective description recorder : markdown ContactDetail [0..1] [0..*] A human-readable string to clarify An individiual, organization, or explain concepts about device primarily responsible for internal coherence of the resource content note editor : Annotation ContactDetail [0..*] An individiual, organization, or device primarily responsible for review of some aspect of the content reviewer : ContactDetail [0..*] An individiual, organization, or device responsible for officially endorsing the content for use in some setting endorser : ContactDetail [0..*] The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances useContext : UsageContext [0..*] A legal or geographic region in which the evidence Explanation of why this Evidence is intended to be used needed and why it has been designed as it has jurisdiction purpose : CodeableConcept [0..*] « Countries and regions within which this artifact is targeted for use. (Strength=Extensible) Jurisdiction ValueSet markdown + » [0..1] A copyright statement relating to the evidence Evidence and/or its contents. Copyright statements are generally legal notices of intellectual property ownership and may include restrictions on the use and publishing of the evidence Evidence copyright : markdown [0..1] A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are restricted. (e.g. 'All rights reserved', 'Some rights reserved') copyrightLabel : string [0..1] A natural language summary of the evidence description : markdown [0..1] Declarative description of the Evidence, such as conclusion or bottom line statement assertion : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] The date on which design of the resource content was approved by synthesis (combination of studies) that produced this evidence. The design is described with any number of synthesis characteristics, such as type of meta-analysis synthesisType : CodeableConcept [0..*] « null (Strength=Example) StatisticSynthesisType ?? » The design of the publisher. Approval happens once when study that produced this evidence. The design is described with any number of study design characteristics studyDesign : CodeableConcept [0..*] « null (Strength=Extensible) StudyDesign + » RelatesTo The type of relationship to the content related artifact type : CodeableConcept [1..1] « null (Strength=Extensible) ArtifactRelationshipType + » The artifact that is officially approved for usage related to this Evidence Resource approvalDate target[x] : date DataType [1..1] « uri | Attachment | canonical ( Any )| Reference ( Any )| markdown » VariableDefinition A text description or summary of the variable description : markdown [0..1] The date on which Footnotes and/or explanatory notes note : Annotation [0..*] Classification of the resource content was last reviewed. Review happens periodically after approval but does not change role of the original approval date variable lastReviewDate variableRole : date code [1..1] « null (Strength=Required) EvidenceVariableRole ! » Sub-classification of the role of the variable roleSubtype : CodeableConcept [0..1] « null (Strength=Example) EvidenceVariableRoleSubtype ?? » The period during which reference value used for comparison comparatorCategory : string [0..1] Definition of the evidence content was or is planned actual variable related to be the statistic(s), i.e., the population being the actual study sample or the measured variable (exposure, outcome, or covariate) being the actual observation that occurred or will occur in active use the study effectivePeriod observed : Period Reference [0..1] « Group | EvidenceVariable » Descriptive topics Definition of the intended variable related to the content of Evidence, i.e., the Evidence. Topics provide a high-level categorization grouping types of Evidences that can be useful population, exposure, or outcome for filtering and searching which the statistical finding is being interpreted topic intended : Reference [0..1] « Group | EvidenceVariable » Indication of quality of match between intended variable to actual variable directnessMatch : CodeableConcept [0..*] [0..1] « High-level categorization null (Strength=Example) EvidenceDirectness ?? » Statistic A natural language summary of the definition, used for searching, sorting, statistic description : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] Type of statistic, e.g., relative risk. The statistic type is a classification that formally defines the relationship between the variables (noted in Evidence.variableDefinition) and filtering. the value specification (noted in Evidence.statistic.quantity) statisticType : CodeableConcept [0..1] « null (Strength=Example) DefinitionTopic StatisticStatisticType ?? » An individiual or organization primarily involved in When the creation measured variable (outcome) is handled categorically, the category element is used to define which category the statistic is reporting category : CodeableConcept [0..1] Statistic value quantity : Quantity [0..1] The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and maintenance sampleSize.numberOfParticipants numberOfEvents : unsignedInt [0..1] The number of participants affected where the unit of analysis is the content same as sampleSize.knownDataCount and sampleSize.numberOfParticipants author numberAffected : ContactDetail unsignedInt [0..1] SampleSize Human-readable summary of study sample size. A human-readable string to clarify or explain concepts about the sample size description : markdown [0..1] Footnote or explanatory note about the sample size note : Annotation [0..*] An individual Count of studies or organization primarily responsible samples combined to become the total sample for internal coherence the statistic numberOfStudies : unsignedInt [0..1] Count of members in the content total sample for the statistic editor numberOfParticipants : ContactDetail unsignedInt [0..*] [0..1] An individual or organization primarily responsible Number of participants with known results for review measured variables knownDataCount : unsignedInt [0..1] Total number of some aspect participants who were analayzed numberAnalyzed : unsignedInt [0..1] AttributeEstimate Human-readable summary of the content estimate reviewer description : ContactDetail markdown [0..*] [0..1] An individual Footnote or organization responsible for officially endorsing explanatory note about the content for use in some setting estimate endorser note : ContactDetail Annotation [0..*] Related artifacts such as additional documentation, justification, The type of attribute estimate, e.g., confidence interval or bibliographic references p value relatedArtifact type : RelatedArtifact CodeableConcept [0..*] [0..1] « null (Strength=Example) StatisticAttributeEstimateType ?? » A reference to a EvidenceVariable resource that defines The singular quantity of the population attribute estimate, for attribute estimates represented as single values, which may include a unit of measure quantity : Quantity [0..1] Use 0.95 for a 95% confidence interval level : decimal [0..1] Lower and upper bound values of the research attribute estimate exposureBackground range : Reference Range [0..1] ModelCharacteristic Description of a component of the method to generate the statistic code : CodeableConcept [1..1] « EvidenceVariable null (Strength=Example) StatisticModelCode ?? » A reference Further specification of the value of the component of the method to a EvidenceVariable resource that defines generate the exposure statistic value[x] : DataType [0..1] « Quantity ( SimpleQuantity )| Range | CodeableConcept » The plan for analysis intended : boolean [0..1] This model characteristic is part of the research analysis that was applied, whether or not the analysis followed the plan exposureVariant applied : boolean [0..1] Variable Description and definition of the variable variableDefinition : Reference [0..*] [1..1] « Group | EvidenceVariable » A reference to a EvidenceVariable resomece that defines How the outcome variable is classified for the research use in adjusted analysis outcome handling : Reference CodeableConcept [0..1] « null (Strength=Example) EvidenceVariableHandlingExamp... ?? » Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable valueCategory : CodeableConcept [0..*] Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable valueQuantity : Quantity [0..*] Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable valueRange : Range [0..*] Certainty Textual description of certainty description : markdown [0..1] Footnotes and/or explanatory notes note : Annotation [0..*] Aspect of certainty being rated type : CodeableConcept [0..1] « EvidenceVariable null (Strength=Example) EvidenceCertaintyType ?? » Assessment or judgement of the aspect rating : CodeableConcept [0..1] « null (Strength=Example) StatisticCertaintyRating ?? » Individual or group who did the rating rater : string [0..*] Relationships that this Evidence has with other FHIR or non-FHIR resources that already exist relatesTo [0..*] Description, classification, and definition of a single variable. The collection of variables defines what the evidence is about variableDefinition [0..*] Count of participants in the study sample sampleSize [0..1] A nested attribute estimate; which is the attribute estimate of an attribute estimate attributeEstimate [0..*] A statistical attribute of the statistic such as a measure of heterogeneity attributeEstimate [0..*] A variable adjusted for in the adjusted analysis variable [0..*] An attribute of the model characteristic attribute [0..*] A component of the method to generate the statistic modelCharacteristic [0..*] Values and parameters for a single statistic statistic [0..*] A domain or subdomain of certainty subcomponent [0..*] Assessment of certainty, confidence in the estimates, or quality of the evidence certainty [0..*]

XML Template 

<

<Evidence xmlns="http://hl7.org/fhir"> doco

 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <
 <</identifier>
 <
 <
 <
 <
 <
 <
 <
 <

 <url value="[uri]"/><!-- 0..1 Canonical identifier for this evidence, represented as a globally unique URI -->
 <identifier><!-- 0..* Identifier Additional identifier for the summary --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of this summary -->
 <versionAlgorithm[x]><!-- 0..1 string|Coding How to compare versions --></versionAlgorithm[x]>
 <name value="[string]"/><!-- I 0..1 Name for this summary (machine friendly) -->
 <title value="[string]"/><!-- 0..1 Name for this summary (human friendly) -->
 <citeAs value="[markdown]"/><!-- 0..1 Display of how to cite this Evidence -->
 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <experimental value="[boolean]"/><!-- 0..1 For testing only - never for real usage -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <approvalDate value="[date]"/><!-- 0..1 When the summary was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the summary was last reviewed by the publisher -->
 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <publisher value="[string]"/><!-- 0..1 Name of the publisher/steward (organization or individual) -->

 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <
 <</note>

 <recorder><!-- 0..* ContactDetail Who entered the data for the evidence --></recorder>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>

 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <</jurisdiction>
 <
 <
 <
 <</effectivePeriod>
 <</topic>
 <</author>
 <</editor>
 <</reviewer>
 <</endorser>
 <</relatedArtifact>
 <</exposureBackground>
 <</exposureVariant>
 <</outcome>

 <purpose value="[markdown]"/><!-- 0..1 Why this Evidence is defined -->
 <copyright value="[markdown]"/><!-- 0..1 Intellectual property ownership, may include restrictions on use -->
 <copyrightLabel value="[string]"/><!-- 0..1 Copyright holder and year(s) -->
 <relatesTo>  <!-- 0..* Relationships to other Resources -->
  <type><!-- 1..1 CodeableConcept documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes icon --></type>
  <target[x]><!-- 1..1 uri|Attachment|canonical(Any)|Reference(Any)|markdown The artifact that is related to this Evidence --></target[x]>
 </relatesTo>
 <description value="[markdown]"/><!-- 0..1 Description of the particular summary -->
 <assertion value="[markdown]"/><!-- 0..1 Declarative description of the Evidence -->
 <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
 <variableDefinition>  <!-- 0..* Description, classification, and definition of a single variable -->
  <description value="[markdown]"/><!-- 0..1 A text description or summary of the variable -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <variableRole value="[code]"/><!-- 1..1 population | exposure | outcome | covariate -->
  <roleSubtype><!-- 0..1 CodeableConcept Sub-classification of the role of the variable icon --></roleSubtype>
  <comparatorCategory value="[string]"/><!-- 0..1 The reference value used for comparison -->
  <observed><!-- 0..1 Reference(EvidenceVariable|Group) Definition of the actual variable related to the statistic(s) --></observed>
  <intended><!-- 0..1 Reference(EvidenceVariable|Group) Definition of the intended variable related to the Evidence --></intended>
  <directnessMatch><!-- 0..1 CodeableConcept low | moderate | high | exact icon --></directnessMatch>
 </variableDefinition>
 <synthesisType><!-- 0..* CodeableConcept The design of the synthesis (combination of studies) that produced this evidence icon --></synthesisType>
 <studyDesign><!-- 0..* CodeableConcept The design of the study that produced this evidence --></studyDesign>
 <statistic>  <!-- 0..* Values and parameters for a single statistic -->
  <description value="[markdown]"/><!-- 0..1 A natural language summary of the statistic -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <statisticType><!-- 0..1 CodeableConcept Type of statistic, e.g., relative risk icon --></statisticType>
  <category><!-- 0..1 CodeableConcept Associated category for categorical variable --></category>
  <quantity><!-- 0..1 Quantity Statistic value --></quantity>
  <numberOfEvents value="[unsignedInt]"/><!-- 0..1 The number of events associated with the statistic -->
  <numberAffected value="[unsignedInt]"/><!-- 0..1 The number of participants affected -->
  <sampleSize>  <!-- 0..1 Count of participants in the study sample -->
   <description value="[markdown]"/><!-- 0..1 Textual description of sample size for statistic -->
   <note><!-- 0..* Annotation Footnote or explanatory note about the sample size --></note>
   <numberOfStudies value="[unsignedInt]"/><!-- 0..1 Number of contributing studies -->
   <numberOfParticipants value="[unsignedInt]"/><!-- 0..1 Total number of participants -->
   <knownDataCount value="[unsignedInt]"/><!-- 0..1 Number of participants with known results for measured variables -->
   <numberAnalyzed value="[unsignedInt]"/><!-- 0..1 Total number of participants who were analayzed -->
  </sampleSize>
  <attributeEstimate>  <!-- 0..* An attribute of the Statistic -->
   <description value="[markdown]"/><!-- 0..1 Textual description of the attribute estimate -->
   <note><!-- 0..* Annotation Footnote or explanatory note about the estimate --></note>
   <type><!-- 0..1 CodeableConcept The type of attribute estimate, e.g., confidence interval or p value icon --></type>
   <quantity><!-- 0..1 Quantity The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure --></quantity>
   <level value="[decimal]"/><!-- 0..1 Level of confidence interval, e.g., 0.95 for 95% confidence interval -->
   <range><!-- 0..1 Range Lower and upper bound values of the attribute estimate --></range>
   <attributeEstimate><!-- 0..* Content as for Evidence.statistic.attributeEstimate A nested attribute estimate; which is the attribute estimate of an attribute estimate --></attributeEstimate>
  </attributeEstimate>
  <modelCharacteristic>  <!-- 0..* An aspect of the statistical model -->
   <code><!-- 1..1 CodeableConcept Model specification icon --></code>
   <value[x]><!-- 0..1 Quantity(SimpleQuantity)|Range|CodeableConcept The specific value (when paired with code) --></value[x]>
   <intended value="[boolean]"/><!-- 0..1 The plan for analysis -->
   <applied value="[boolean]"/><!-- 0..1 This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan -->
   <variable>  <!-- 0..* A variable adjusted for in the adjusted analysis -->
    <variableDefinition><!-- 1..1 Reference(EvidenceVariable|Group) Description and definition of the variable --></variableDefinition>
    <handling><!-- 0..1 CodeableConcept boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified --></handling>
    <valueCategory><!-- 0..* CodeableConcept Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueCategory>
    <valueQuantity><!-- 0..* Quantity Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueQuantity>
    <valueRange><!-- 0..* Range Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable --></valueRange>
   </variable>
   <attribute><!-- 0..* Content as for Evidence.statistic.attributeEstimate An attribute of the model characteristic --></attribute>
  </modelCharacteristic>
 </statistic>
 <certainty>  <!-- 0..* Certainty or quality of the evidence -->
  <description value="[markdown]"/><!-- 0..1 Textual description of certainty -->
  <note><!-- 0..* Annotation Footnotes and/or explanatory notes --></note>
  <type><!-- 0..1 CodeableConcept Aspect of certainty being rated icon --></type>
  <rating><!-- 0..1 CodeableConcept Assessment or judgement of the aspect icon --></rating>
  <rater value="[string]"/><!-- 0..* Individual or group who did the rating -->
  <subcomponent><!-- 0..* Content as for Evidence.certainty A domain or subdomain of certainty --></subcomponent>
 </certainty>

</Evidence>

JSON Template 

{doco
  "resourceType" : "",

  "resourceType" : "Evidence",

  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "

  "url" : "<uri>", // Canonical identifier for this evidence, represented as a globally unique URI
  "identifier" : [{ Identifier }], // Additional identifier for the summary
  "version" : "<string>", // Business version of this summary
  // versionAlgorithm[x]: How to compare versions. One of these 2:

  "versionAlgorithmString" : "<string>",
  "versionAlgorithmCoding" : { Coding },
  "name" : "<string>", // I Name for this summary (machine friendly)
  "title" : "<string>", // Name for this summary (human friendly)
  "citeAs" : "<markdown>", // Display of how to cite this Evidence
  "status" : "<code>", // R!  draft | active | retired | unknown
  "experimental" : <boolean>, // For testing only - never for real usage
  "date" : "<dateTime>", // Date last changed
  "approvalDate" : "<date>", // When the summary was approved by publisher
  "lastReviewDate" : "<date>", // When the summary was last reviewed by the publisher
  "author" : [{ ContactDetail }], // Who authored the content
  "publisher" : "<string>", // Name of the publisher/steward (organization or individual)

  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "
  "

  "recorder" : [{ ContactDetail }], // Who entered the data for the evidence
  "editor" : [{ ContactDetail }], // Who edited the content
  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content

  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "
  "

  "purpose" : "<markdown>", // Why this Evidence is defined
  "copyright" : "<markdown>", // Intellectual property ownership, may include restrictions on use
  "copyrightLabel" : "<string>", // Copyright holder and year(s)
  "relatesTo" : [{ // Relationships to other Resources
    "type" : { CodeableConcept }, // R!  documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes icon
    // target[x]: The artifact that is related to this Evidence. One of these 5:

    "targetUri" : "<uri>",
    "targetAttachment" : { Attachment },
    "targetCanonical" : "<canonical(Any)>",
    "targetReference" : { Reference(Any) },
    "targetMarkdown" : "<markdown>"
  }],
  "description" : "<markdown>", // Description of the particular summary
  "assertion" : "<markdown>", // Declarative description of the Evidence
  "note" : [{ Annotation }], // Footnotes and/or explanatory notes
  "variableDefinition" : [{ // Description, classification, and definition of a single variable
    "description" : "<markdown>", // A text description or summary of the variable
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "variableRole" : "<code>", // R!  population | exposure | outcome | covariate
    "roleSubtype" : { CodeableConcept }, // Sub-classification of the role of the variable icon
    "comparatorCategory" : "<string>", // The reference value used for comparison
    "observed" : { Reference(EvidenceVariable|Group) }, // Definition of the actual variable related to the statistic(s)
    "intended" : { Reference(EvidenceVariable|Group) }, // Definition of the intended variable related to the Evidence
    "directnessMatch" : { CodeableConcept } // low | moderate | high | exact icon
  }],
  "synthesisType" : [{ CodeableConcept }], // The design of the synthesis (combination of studies) that produced this evidence icon
  "studyDesign" : [{ CodeableConcept }], // The design of the study that produced this evidence
  "statistic" : [{ // Values and parameters for a single statistic
    "description" : "<markdown>", // A natural language summary of the statistic
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "statisticType" : { CodeableConcept }, // Type of statistic, e.g., relative risk icon
    "category" : { CodeableConcept }, // Associated category for categorical variable
    "quantity" : { Quantity }, // Statistic value
    "numberOfEvents" : "<unsignedInt>", // The number of events associated with the statistic
    "numberAffected" : "<unsignedInt>", // The number of participants affected
    "sampleSize" : { // Count of participants in the study sample
      "description" : "<markdown>", // Textual description of sample size for statistic
      "note" : [{ Annotation }], // Footnote or explanatory note about the sample size
      "numberOfStudies" : "<unsignedInt>", // Number of contributing studies
      "numberOfParticipants" : "<unsignedInt>", // Total number of participants
      "knownDataCount" : "<unsignedInt>", // Number of participants with known results for measured variables
      "numberAnalyzed" : "<unsignedInt>" // Total number of participants who were analayzed
    },
    "attributeEstimate" : [{ // An attribute of the Statistic
      "description" : "<markdown>", // Textual description of the attribute estimate
      "note" : [{ Annotation }], // Footnote or explanatory note about the estimate
      "type" : { CodeableConcept }, // The type of attribute estimate, e.g., confidence interval or p value icon
      "quantity" : { Quantity }, // The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
      "level" : <decimal>, // Level of confidence interval, e.g., 0.95 for 95% confidence interval
      "range" : { Range }, // Lower and upper bound values of the attribute estimate
      "attributeEstimate" : [{ Content as for Evidence.statistic.attributeEstimate }] // A nested attribute estimate; which is the attribute estimate of an attribute estimate
    }],
    "modelCharacteristic" : [{ // An aspect of the statistical model
      "code" : { CodeableConcept }, // R!  Model specification icon
      // value[x]: The specific value (when paired with code). One of these 3:

      "valueQuantity" : { Quantity(SimpleQuantity) },
      "valueRange" : { Range },
      "valueCodeableConcept" : { CodeableConcept },
      "intended" : <boolean>, // The plan for analysis
      "applied" : <boolean>, // This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
      "variable" : [{ // A variable adjusted for in the adjusted analysis
        "variableDefinition" : { Reference(EvidenceVariable|Group) }, // R!  Description and definition of the variable
        "handling" : { CodeableConcept }, // boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
        "valueCategory" : [{ CodeableConcept }], // Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        "valueQuantity" : [{ Quantity }], // Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        "valueRange" : [{ Range }] // Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
      }],
      "attribute" : [{ Content as for Evidence.statistic.attributeEstimate }] // An attribute of the model characteristic
    }]
  }],
  "certainty" : [{ // Certainty or quality of the evidence
    "description" : "<markdown>", // Textual description of certainty
    "note" : [{ Annotation }], // Footnotes and/or explanatory notes
    "type" : { CodeableConcept }, // Aspect of certainty being rated icon
    "rating" : { CodeableConcept }, // Assessment or judgement of the aspect icon
    "rater" : ["<string>"], // Individual or group who did the rating
    "subcomponent" : [{ Content as for Evidence.certainty }] // A domain or subdomain of certainty
  }]

}

Turtle Template 

@prefix fhir: <http://hl7.org/fhir/> .doco


[ a fhir:;

[ a fhir:Evidence;

  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from 
  # from 
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
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  fhir:
  fhir:
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  fhir:
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  fhir:
  fhir:
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  fhir:
  fhir:

  # from Resource: fhir:id, fhir:meta, fhir:implicitRules, and fhir:language
  # from DomainResource: fhir:text, fhir:contained, fhir:extension, and fhir:modifierExtension
  fhir:url [ uri ] ; # 0..1 Canonical identifier for this evidence, represented as a globally unique URI
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Additional identifier for the summary
  fhir:version [ string ] ; # 0..1 Business version of this summary
  # versionAlgorithm[x] : 0..1 How to compare versions. One of these 2
    fhir:versionAlgorithm [  a fhir:String ; string ]
    fhir:versionAlgorithm [  a fhir:Coding ; Coding ]
  fhir:name [ string ] ; # 0..1 I Name for this summary (machine friendly)
  fhir:title [ string ] ; # 0..1 Name for this summary (human friendly)
  fhir:citeAs [ markdown ] ; # 0..1 Display of how to cite this Evidence
  fhir:status [ code ] ; # 1..1 draft | active | retired | unknown
  fhir:experimental [ boolean ] ; # 0..1 For testing only - never for real usage
  fhir:date [ dateTime ] ; # 0..1 Date last changed
  fhir:approvalDate [ date ] ; # 0..1 When the summary was approved by publisher
  fhir:lastReviewDate [ date ] ; # 0..1 When the summary was last reviewed by the publisher
  fhir:author  ( [ ContactDetail ] ... ) ; # 0..* Who authored the content
  fhir:publisher [ string ] ; # 0..1 Name of the publisher/steward (organization or individual)
  fhir:contact  ( [ ContactDetail ] ... ) ; # 0..* Contact details for the publisher
  fhir:recorder  ( [ ContactDetail ] ... ) ; # 0..* Who entered the data for the evidence
  fhir:editor  ( [ ContactDetail ] ... ) ; # 0..* Who edited the content
  fhir:reviewer  ( [ ContactDetail ] ... ) ; # 0..* Who reviewed the content
  fhir:endorser  ( [ ContactDetail ] ... ) ; # 0..* Who endorsed the content
  fhir:useContext  ( [ UsageContext ] ... ) ; # 0..* The context that the content is intended to support
  fhir:purpose [ markdown ] ; # 0..1 Why this Evidence is defined
  fhir:copyright [ markdown ] ; # 0..1 Intellectual property ownership, may include restrictions on use
  fhir:copyrightLabel [ string ] ; # 0..1 Copyright holder and year(s)
  fhir:relatesTo ( [ # 0..* Relationships to other Resources
    fhir:type [ CodeableConcept ] ; # 1..1 documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes
    # target[x] : 1..1 The artifact that is related to this Evidence. One of these 5
      fhir:target [  a fhir:Uri ; uri ]
      fhir:target [  a fhir:Attachment ; Attachment ]
      fhir:target [  a fhir:Canonical ; canonical(Any) ]
      fhir:target [  a fhir:Reference ; Reference(Any) ]
      fhir:target [  a fhir:Markdown ; markdown ]
  ] ... ) ;
  fhir:description [ markdown ] ; # 0..1 Description of the particular summary
  fhir:assertion [ markdown ] ; # 0..1 Declarative description of the Evidence
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
  fhir:variableDefinition ( [ # 0..* Description, classification, and definition of a single variable
    fhir:description [ markdown ] ; # 0..1 A text description or summary of the variable
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:variableRole [ code ] ; # 1..1 population | exposure | outcome | covariate
    fhir:roleSubtype [ CodeableConcept ] ; # 0..1 Sub-classification of the role of the variable
    fhir:comparatorCategory [ string ] ; # 0..1 The reference value used for comparison
    fhir:observed [ Reference(EvidenceVariable|Group) ] ; # 0..1 Definition of the actual variable related to the statistic(s)
    fhir:intended [ Reference(EvidenceVariable|Group) ] ; # 0..1 Definition of the intended variable related to the Evidence
    fhir:directnessMatch [ CodeableConcept ] ; # 0..1 low | moderate | high | exact
  ] ... ) ;
  fhir:synthesisType  ( [ CodeableConcept ] ... ) ; # 0..* The design of the synthesis (combination of studies) that produced this evidence
  fhir:studyDesign  ( [ CodeableConcept ] ... ) ; # 0..* The design of the study that produced this evidence
  fhir:statistic ( [ # 0..* Values and parameters for a single statistic
    fhir:description [ markdown ] ; # 0..1 A natural language summary of the statistic
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:statisticType [ CodeableConcept ] ; # 0..1 Type of statistic, e.g., relative risk
    fhir:category [ CodeableConcept ] ; # 0..1 Associated category for categorical variable
    fhir:quantity [ Quantity ] ; # 0..1 Statistic value
    fhir:numberOfEvents [ unsignedInt ] ; # 0..1 The number of events associated with the statistic
    fhir:numberAffected [ unsignedInt ] ; # 0..1 The number of participants affected
    fhir:sampleSize [ # 0..1 Count of participants in the study sample
      fhir:description [ markdown ] ; # 0..1 Textual description of sample size for statistic
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnote or explanatory note about the sample size
      fhir:numberOfStudies [ unsignedInt ] ; # 0..1 Number of contributing studies
      fhir:numberOfParticipants [ unsignedInt ] ; # 0..1 Total number of participants
      fhir:knownDataCount [ unsignedInt ] ; # 0..1 Number of participants with known results for measured variables
      fhir:numberAnalyzed [ unsignedInt ] ; # 0..1 Total number of participants who were analayzed
    ] ;
    fhir:attributeEstimate ( [ # 0..* An attribute of the Statistic
      fhir:description [ markdown ] ; # 0..1 Textual description of the attribute estimate
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnote or explanatory note about the estimate
      fhir:type [ CodeableConcept ] ; # 0..1 The type of attribute estimate, e.g., confidence interval or p value
      fhir:quantity [ Quantity ] ; # 0..1 The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
      fhir:level [ decimal ] ; # 0..1 Level of confidence interval, e.g., 0.95 for 95% confidence interval
      fhir:range [ Range ] ; # 0..1 Lower and upper bound values of the attribute estimate
      fhir:attributeEstimate  ( [ See Evidence.statistic.attributeEstimate ] ... ) ; # 0..* A nested attribute estimate; which is the attribute estimate of an attribute estimate
    ] ... ) ;
    fhir:modelCharacteristic ( [ # 0..* An aspect of the statistical model
      fhir:code [ CodeableConcept ] ; # 1..1 Model specification
      # value[x] : 0..1 The specific value (when paired with code). One of these 3
        fhir:value [  a fhir:SimpleQuantity ; Quantity(SimpleQuantity) ]
        fhir:value [  a fhir:Range ; Range ]
        fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:intended [ boolean ] ; # 0..1 The plan for analysis
      fhir:applied [ boolean ] ; # 0..1 This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
      fhir:variable ( [ # 0..* A variable adjusted for in the adjusted analysis
        fhir:variableDefinition [ Reference(EvidenceVariable|Group) ] ; # 1..1 Description and definition of the variable
        fhir:handling [ CodeableConcept ] ; # 0..1 boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified
        fhir:valueCategory  ( [ CodeableConcept ] ... ) ; # 0..* Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        fhir:valueQuantity  ( [ Quantity ] ... ) ; # 0..* Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
        fhir:valueRange  ( [ Range ] ... ) ; # 0..* Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
      ] ... ) ;
      fhir:attribute  ( [ See Evidence.statistic.attributeEstimate ] ... ) ; # 0..* An attribute of the model characteristic
    ] ... ) ;
  ] ... ) ;
  fhir:certainty ( [ # 0..* Certainty or quality of the evidence
    fhir:description [ markdown ] ; # 0..1 Textual description of certainty
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Footnotes and/or explanatory notes
    fhir:type [ CodeableConcept ] ; # 0..1 Aspect of certainty being rated
    fhir:rating [ CodeableConcept ] ; # 0..1 Assessment or judgement of the aspect
    fhir:rater  ( [ string ] ... ) ; # 0..* Individual or group who did the rating
    fhir:subcomponent  ( [ See Evidence.certainty ] ... ) ; # 0..* A domain or subdomain of certainty
  ] ... ) ;

]

Changes since Release 3 from R5 to R6

Evidence
Evidence.citeAs
  • Renamed from citeAs[x] to citeAs
  • Remove Type Reference(Citation)
Evidence.recorder
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.variableDefinition
  • Min Cardinality changed from 1 to 0
Evidence.variableDefinition.variableRole
  • Type changed from CodeableConcept to code
  • Change binding strength from extensible to required
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Remove Binding `http://terminology.hl7.org/ValueSet/directness` (extensible)
Evidence.synthesisType
  • Max Cardinality changed from 1 to *
  • Remove Binding `http://terminology.hl7.org/ValueSet/synthesis-type` (extensible)
Evidence.studyDesign
  • Change code system for extensibly bound codes from "http://hl7.org/fhir/study-design" to "https://fevir.net/sevco"
Evidence.statistic.statisticType
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-type` (extensible)
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/attribute-estimate-type` (extensible)
Evidence.statistic.modelCharacteristic.code
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-model-code` (extensible)
Evidence.statistic.modelCharacteristic.value[x]
  • Renamed from value to value[x]
  • Add Types Range, CodeableConcept
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Type changed from code to CodeableConcept
  • Remove Binding `http://hl7.org/fhir/ValueSet/variable-handling|5.0.0` (required)
Evidence.statistic.modelCharacteristic.attribute
  • Renamed from attributeEstimate to attribute
Evidence.certainty.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-type` (extensible)
Evidence.certainty.rating
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-rating` (extensible)
Evidence.certainty.rater
  • Max Cardinality changed from 1 to *
Evidence.relatedArtifact
  • Deleted

This resource did not exist in Release 2 Changes from R4B to R6

Evidence
Evidence.versionAlgorithm[x]
  • Added Element
Evidence.name
  • Added Element
Evidence.citeAs
  • Renamed from citeAs[x] to citeAs
  • Remove Type Reference(Citation)
Evidence.experimental
  • Added Element
Evidence.recorder
  • Added Element
Evidence.purpose
  • Added Element
Evidence.copyright
  • Added Element
Evidence.copyrightLabel
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.variableDefinition
  • Min Cardinality changed from 1 to 0
Evidence.variableDefinition.variableRole
  • Type changed from CodeableConcept to code
  • Change binding strength from extensible to required
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Remove Binding `http://hl7.org/fhir/ValueSet/directness` (extensible)
Evidence.synthesisType
  • Max Cardinality changed from 1 to *
  • Remove Binding `http://hl7.org/fhir/ValueSet/synthesis-type` (extensible)
Evidence.studyDesign
  • Added Element
Evidence.statistic.description
  • Type changed from string to markdown
Evidence.statistic.statisticType
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-type` (extensible)
Evidence.statistic.sampleSize.description
  • Type changed from string to markdown
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate.description
  • Type changed from string to markdown
Evidence.statistic.attributeEstimate.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/attribute-estimate-type` (extensible)
Evidence.statistic.modelCharacteristic.code
  • Remove Binding `http://hl7.org/fhir/ValueSet/statistic-model-code` (extensible)
Evidence.statistic.modelCharacteristic.value[x]
  • Renamed from value to value[x]
  • Add Types Range, CodeableConcept
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Type changed from code to CodeableConcept
  • Remove Binding `http://hl7.org/fhir/ValueSet/variable-handling|4.3.0` (required)
Evidence.statistic.modelCharacteristic.attribute
  • Added Element
Evidence.certainty.description
  • Type changed from string to markdown
Evidence.certainty.type
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-type` (extensible)
Evidence.certainty.rating
  • Remove Binding `http://hl7.org/fhir/ValueSet/certainty-rating` (extensible)
Evidence.certainty.rater
  • Max Cardinality changed from 1 to *
Evidence.relatedArtifact
  • Deleted
Evidence.studyType
  • Deleted
Evidence.statistic.modelCharacteristic.attributeEstimate
  • Deleted

Changes from R4 to R6

Evidence
Evidence.versionAlgorithm[x]
  • Added Element
Evidence.citeAs
  • Added Element
Evidence.experimental
  • Added Element
Evidence.recorder
  • Added Element
Evidence.purpose
  • Added Element
Evidence.copyrightLabel
  • Added Element
Evidence.relatesTo
  • Added Element
Evidence.relatesTo.type
  • Added Mandatory Element
Evidence.relatesTo.target[x]
  • Added Mandatory Element
Evidence.assertion
  • Added Element
Evidence.variableDefinition
  • Added Element
Evidence.variableDefinition.description
  • Added Element
Evidence.variableDefinition.note
  • Added Element
Evidence.variableDefinition.variableRole
  • Added Mandatory Element
Evidence.variableDefinition.roleSubtype
  • Added Element
Evidence.variableDefinition.comparatorCategory
  • Added Element
Evidence.variableDefinition.observed
  • Added Element
Evidence.variableDefinition.intended
  • Added Element
Evidence.variableDefinition.directnessMatch
  • Added Element
Evidence.synthesisType
  • Added Element
Evidence.studyDesign
  • Added Element
Evidence.statistic
  • Added Element
Evidence.statistic.description
  • Added Element
Evidence.statistic.note
  • Added Element
Evidence.statistic.statisticType
  • Added Element
Evidence.statistic.category
  • Added Element
Evidence.statistic.quantity
  • Added Element
Evidence.statistic.numberOfEvents
  • Added Element
Evidence.statistic.numberAffected
  • Added Element
Evidence.statistic.sampleSize
  • Added Element
Evidence.statistic.sampleSize.description
  • Added Element
Evidence.statistic.sampleSize.note
  • Added Element
Evidence.statistic.sampleSize.numberOfStudies
  • Added Element
Evidence.statistic.sampleSize.numberOfParticipants
  • Added Element
Evidence.statistic.sampleSize.knownDataCount
  • Added Element
Evidence.statistic.sampleSize.numberAnalyzed
  • Added Element
Evidence.statistic.attributeEstimate
  • Added Element
Evidence.statistic.attributeEstimate.description
  • Added Element
Evidence.statistic.attributeEstimate.note
  • Added Element
Evidence.statistic.attributeEstimate.type
  • Added Element
Evidence.statistic.attributeEstimate.quantity
  • Added Element
Evidence.statistic.attributeEstimate.level
  • Added Element
Evidence.statistic.attributeEstimate.range
  • Added Element
Evidence.statistic.attributeEstimate.attributeEstimate
  • Added Element
Evidence.statistic.modelCharacteristic
  • Added Element
Evidence.statistic.modelCharacteristic.code
  • Added Mandatory Element
Evidence.statistic.modelCharacteristic.value[x]
  • Added Element
Evidence.statistic.modelCharacteristic.intended
  • Added Element
Evidence.statistic.modelCharacteristic.applied
  • Added Element
Evidence.statistic.modelCharacteristic.variable
  • Added Element
Evidence.statistic.modelCharacteristic.variable.variableDefinition
  • Added Mandatory Element
Evidence.statistic.modelCharacteristic.variable.handling
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueCategory
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueQuantity
  • Added Element
Evidence.statistic.modelCharacteristic.variable.valueRange
  • Added Element
Evidence.statistic.modelCharacteristic.attribute
  • Added Element
Evidence.certainty
  • Added Element
Evidence.certainty.description
  • Added Element
Evidence.certainty.note
  • Added Element
Evidence.certainty.type
  • Added Element
Evidence.certainty.rating
  • Added Element
Evidence.certainty.rater
  • Added Element
Evidence.certainty.subcomponent
  • Added Element
Evidence.shortTitle
  • Deleted
Evidence.subtitle
  • Deleted
Evidence.jurisdiction
  • Deleted
Evidence.effectivePeriod
  • Deleted
Evidence.topic
  • Deleted
Evidence.relatedArtifact
  • Deleted
Evidence.exposureBackground
  • Deleted
Evidence.exposureVariant
  • Deleted
Evidence.outcome
  • Deleted

See the Full Difference for further information

This analysis is available for R4 as XML or JSON and for R4B as XML or JSON .

 

See the Profiles & Extensions and the alternate Additional definitions: Master Definition XML + JSON , XML Schema / Schematron + JSON Schema , ShEx (for Turtle ) + see , the extensions spreadsheet version & the dependency analysis

14.9.3.1 17.10.4.1 Terminology Bindings

Evidence.jurisdiction Evidence.topic
Path Definition ValueSet Type Reference Documentation
Evidence.versionAlgorithm[x] VersionAlgorithm Extensible

Indicates the mechanism used to compare versions to determine which is more current.

Evidence.status PublicationStatus Required

The lifecycle status of an artifact.

Evidence.relatesTo.type ArtifactRelationshipType icon Extensible

Type of relationship to the related artifact.

Evidence.variableDefinition.variableRole EvidenceVariableRole (a valid code from VariableRole ) Required

The role that the variable plays.

Evidence.variableDefinition.roleSubtype EvidenceVariableRoleSubtype icon Example PublicationStatus

The subclassification of the role that the assertion variable plays.

Evidence.variableDefinition.directnessMatch EvidenceDirectness icon Example

The quality of how direct the match is.

Evidence.synthesisType StatisticSynthesisType icon Example Countries and regions within which this artifact is targeted for use.

Types of combining results from a body of evidence (eg. summary data meta-analysis).

Evidence.studyDesign StudyDesign Extensible

This is a set of terms for study design characteristics.

Evidence.statistic.statisticType Jurisdiction ValueSet StatisticStatisticType icon Example

The type of a specific statistic.

Evidence.statistic.attributeEstimate.type StatisticAttributeEstimateType icon Example High-level categorization

Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.

Evidence.statistic.modelCharacteristic.code StatisticModelCode icon Example

The handling of the definition, used variable in statistical analysis for searching, sorting, and filtering. exposures or outcomes.

Evidence.statistic.modelCharacteristic.variable.handling EvidenceVariableHandlingExample Example

The handling of the variable in statistical analysis for exposures or outcomes (E.g. Dichotomous, Continuous, Descriptive).

Evidence.certainty.type DefinitionTopic EvidenceCertaintyType icon Example

The aspect of quality, confidence, or certainty.

Evidence.certainty.rating StatisticCertaintyRating icon Example

The relative quality of the statistic.

14.9.3.2 17.10.4.2 Constraints

id UniqueKey Level Location Description Expression
evi-0 img  cnl-0 Warning (base) Name should be usable as an identifier for the module by machine processing applications such as code generation name.matches('[A-Z]([A-Za-z0-9_]){0,254}') name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
img  cnl-1 Warning Evidence.url URL should not contain | or # - these characters make processing canonical references problematic exists() implies matches('^[^|# ]+$')



14.9.4 17.10.5 Search Parameters

Search parameters for this resource. See also the full list of search parameters for this resource , and check the Extensions registry for search parameters on extensions related to this resource. The common parameters also apply. See Searching for more information about searching in REST, messaging, and services.

What resource is being referenced Evidence.relatedArtifact.where(type='composed-of').resource (Any) context depends-on What resource is being referenced Evidence.relatedArtifact.where(type='depends-on').resource (Any) What resource is being referenced Evidence.relatedArtifact.where(type='derived-from').resource (Any) description jurisdiction token Computationally friendly name of the evidence Evidence.name What resource is being referenced Evidence.relatedArtifact.where(type='predecessor').resource (Any) publisher successor What resource is being referenced Evidence.relatedArtifact.where(type='successor').resource (Any) topic Topics associated with the Evidence Evidence.topic
Name Type Description Expression In Common
composed-of reference context token A use context assigned to the evidence (Evidence.useContext.value as CodeableConcept) (Evidence.useContext.value.ofType(CodeableConcept)) 24 Resources
context-quantity quantity A quantity- or range-valued use context assigned to the evidence (Evidence.useContext.value as Quantity) (Evidence.useContext.value.ofType(Quantity)) | (Evidence.useContext.value as Range) (Evidence.useContext.value.ofType(Range)) 24 Resources
context-type token A type of use context assigned to the evidence Evidence.useContext.code 24 Resources
context-type-quantity composite A use context type and quantity- or range-based value assigned to the evidence On Evidence.useContext:
  context-type: code
  context-quantity: value.as(Quantity) value.ofType(Quantity) | value.as(Range) value.ofType(Range) 		24 Resources
context-type-value composite A use context type and value assigned to the evidence On Evidence.useContext:
  context-type: code
  context: value.as(CodeableConcept) value.ofType(CodeableConcept) 		24 Resources
date date The evidence publication date Evidence.date reference 25 Resources
derived-from reference description string The description of the evidence Evidence.description 23 Resources
experimental effective date token The time during which Whether the evidence Evidence is intended to be in use experimental Evidence.effectivePeriod Evidence.experimental
identifier token External identifier for the evidence Evidence.identifier Intended jurisdiction for the evidence Evidence.jurisdiction name string 28 Resources
predecessor reference publisher string Name of the publisher of the evidence Evidence.publisher 25 Resources
status token The current status of the evidence Evidence.status reference 28 Resources
title string The human-friendly name of the evidence Evidence.title token 23 Resources
url uri The uri that identifies the evidence Evidence.url 29 Resources
version token The business version of the evidence Evidence.version 26 Resources