14.10 14.14 Resource EvidenceVariable - Content

Name	Flags	Card.	Type	Description & Constraints
EvidenceVariable	I TU		DomainResource	A population, intervention, or exposure definition of an exposure, outcome, or other variable + Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension Interfaces Implemented: MetadataResource
url	Σ C	0..1	uri	Canonical identifier for this evidence variable, represented as a URI (globally unique) + Warning: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Additional identifier for the evidence variable
version	Σ	0..1	string	Business version of the evidence variable
name versionAlgorithm[x]	Σ I	0..1		How to compare versions Binding: Version Algorithm ( Extensible )
versionAlgorithmString			string
versionAlgorithmCoding		Name for this evidence variable (computer friendly)	Coding
title name	Σ C	0..1	string	Name for this evidence variable (human (computer friendly)
shortTitle title	Σ	0..1	string	Title Name for use in informal contexts this evidence variable (human friendly)
subtitle shortTitle	Σ	0..1	string	Subordinate title of the EvidenceVariable Title for use in informal contexts
status	?! Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus ( Required )
date experimental		0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
publisher	Σ	0..1	string	Name of the publisher publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
description	Σ	0..1	markdown	Natural language description of the evidence variable
note		0..*	Annotation	Used for footnotes or explanatory notes
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
jurisdiction purpose	Σ	0..1	markdown	Why this EvidenceVariable is defined
copyright		Intended jurisdiction for evidence variable (if applicable) 0..1	markdown )	Use and/or publishing restrictions
copyright copyrightLabel	T	0..1	markdown string	Use and/or publishing restrictions Copyright holder and year(s)
approvalDate		0..1	date	When the evidence variable resource was approved by publisher
lastReviewDate		0..1	date	When the evidence variable resource was last reviewed by the publisher
effectivePeriod		0..1	Period	When the evidence variable resource is expected to be used
topic author		0..*	CodeableConcept ContactDetail	The category of Who authored the EvidenceVariable, such as Education, Treatment, Assessment, etc. content DefinitionTopic ( Example )
author editor		0..*	ContactDetail	Who authored edited the content
editor reviewer		0..*	ContactDetail	Who edited reviewed the content
reviewer endorser		0..*	ContactDetail	Who reviewed endorsed the content
endorser relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc
actual		0..1	boolean	Actual or conceptual
characteristic	Σ C	0..*	ContactDetail BackboneElement	Who endorsed A defining factor of the content EvidenceVariable + Rule: In a characteristic, at most one of these six elements shall be used: definitionReference or definitionCanonical or definitionCodeableConcept or definitionId or definitionByTypeAndValue or definitionByCombination
relatedArtifact linkId		0..1	id	Label for internal linking
description		0..1	markdown	Natural language description of the characteristic
note		0..*	RelatedArtifact Annotation	Additional documentation, citations, etc. Used for footnotes or explanatory notes
type exclude		0..1	boolean	Whether the characteristic is an inclusion criterion or exclusion criterion
definitionReference	Σ C	0..1	Reference ( EvidenceVariable | Group | Evidence )	Defines the characteristic (without using type and value) by a Reference
definitionCanonical	code Σ C	dichotomous | continuous | descriptive 0..1	canonical ( Required EvidenceVariable | Evidence )	Defines the characteristic (without using type and value) by a Canonical
characteristic definitionCodeableConcept	Σ C	1..* 0..1	BackboneElement CodeableConcept	What defines the members of Defines the evidence element characteristic (without using type and value) by a CodeableConcept
description definitionExpression	Σ	0..1	string Expression	Natural language description of Defines the characteristic (without using type and value) by an expression
definition[x] definitionId	Σ C	1..1 0..1	id	What code or expression defines members? Defines the characteristic (without using type and value) by an id
definitionByTypeAndValue definitionReference	Σ C	0..1	Reference ( Group BackboneElement )	Defines the characteristic using type and value
definitionCanonical type	Σ	1..1	CodeableConcept	Expresses the type of characteristic Binding: UsageContextType canonical ( ActivityDefinition Example )
definitionCodeableConcept method		0..*	CodeableConcept	Method for how the characteristic value was determined Binding: Definition Method ( Example )
device		0..1	Reference ( Device | DeviceMetric )	Device used for determining characteristic
value[x]	CodeableConcept Σ	1..1		Defines the characteristic when coupled with characteristic.type
definitionExpression valueCodeableConcept			CodeableConcept	Expression
valueBoolean			boolean
valueQuantity			Quantity
definitionDataRequirement valueRange			Range	DataRequirement
valueReference			Reference ()
definitionTriggerDefinition valueId			id
offset		0..1	TriggerDefinition CodeableConcept	Reference point for valueQuantity or valueRange Binding: Characteristic Offset ( Example )
usageContext definitionByCombination	C	0..* 0..1	UsageContext BackboneElement	What code/value pairs define members? Used to specify how two or more characteristics are combined
exclude code		1..1	code	all-of | any-of | at-least | at-most | statistical | net-effect | dataset Binding: Characteristic Combination ( Required )
threshold		0..1	positiveInt	Provides the value of "n" when "at-least" or "at-most" codes are used
characteristic		1..*	see characteristic	Whether A defining factor of the characteristic includes or excludes members
participantEffective[x] instances[x]		0..1		What time period do participants cover Number of occurrences meeting the characteristic
participantEffectiveDateTime instancesQuantity			Quantity	dateTime
instancesRange			Range
duration[x]		0..1		Length of time in which the characteristic is met
participantEffectivePeriod durationQuantity			Quantity
durationRange			Range
timeFromEvent		0..*	BackboneElement	Timing in which the characteristic is determined
participantEffectiveDuration description		0..1	markdown	Human readable description Duration
note		0..*	Annotation	Used for footnotes or explanatory notes
event[x]		0..1		The event used as a base point (reference point) in time Binding: Evidence Variable Event ( Example )
participantEffectiveTiming eventCodeableConcept			CodeableConcept	Timing
eventReference			Reference ()
timeFromStart eventDateTime			dateTime
eventId			id
quantity		0..1	Duration Quantity	Used to express the observation at a defined amount of time from study start before or after the event
groupMeasure range		0..1	Range	Used to express the observation within a period before and/or after the event
handling		0..1	code	mean | median | mean-of-mean continuous | mean-of-median dichotomous | median-of-mean ordinal | median-of-median polychotomous GroupMeasure Binding: Evidence Variable Handling ( Required )
category		0..*	BackboneElement	A grouping for ordinal or polychotomous variables
name		0..1	string	Description of the grouping
value[x]		0..1		Definition of the grouping
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueRange			Range
Documentation for this format

See the Extensions for this resource

<

<EvidenceVariable xmlns="http://hl7.org/fhir"> 

 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <

 <url value="[uri]"/><!-- 0..1 Canonical identifier for this evidence variable, represented as a URI (globally unique) -->

 <identifier><!-- 0..* Identifier Additional identifier for the evidence variable --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of the evidence variable -->
 <

 <versionAlgorithm[x]><!-- 0..1 string|Coding How to compare versions --></versionAlgorithm[x]>
 <name value="[string]"/><!-- I 0..1 Name for this evidence variable (computer friendly) -->

 <title value="[string]"/><!-- 0..1 Name for this evidence variable (human friendly) -->
 <shortTitle value="[string]"/><!-- 0..1 Title for use in informal contexts -->
 <

 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <
 <

 <experimental value="[boolean]"/><!-- 0..1 For testing purposes, not real usage -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <publisher value="[string]"/><!-- 0..1 Name of the publisher/steward (organization or individual) -->

 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <description value="[markdown]"/><!-- 0..1 Natural language description of the evidence variable -->
 <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <</jurisdiction>
 <
 <
 <
 <</effectivePeriod>
 <</topic>

 <purpose value="[markdown]"/><!-- 0..1 Why this EvidenceVariable is defined -->
 <copyright value="[markdown]"/><!-- 0..1 Use and/or publishing restrictions -->
 <copyrightLabel value="[string]"/><!-- 0..1 Copyright holder and year(s) -->
 <approvalDate value="[date]"/><!-- 0..1 When the resource was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the resource was last reviewed by the publisher -->
 <effectivePeriod><!-- 0..1 Period When the resource is expected to be used --></effectivePeriod>

 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <</reviewer>
 <</endorser>
 <</relatedArtifact>
 <
 <
  <
  <)|
    </definition[x]>
  <</usageContext>
  <
  <</participantEffective[x]>
  <</timeFromStart>
  <

 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>
 <relatedArtifact><!-- 0..* RelatedArtifact Additional documentation, citations, etc --></relatedArtifact>
 <actual value="[boolean]"/><!-- 0..1 Actual or conceptual -->
 <characteristic>  <!-- 0..* A defining factor of the EvidenceVariable -->
  <linkId value="[id]"/><!-- 0..1 Label for internal linking -->
  <description value="[markdown]"/><!-- 0..1 Natural language description of the characteristic -->
  <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  <exclude value="[boolean]"/><!-- 0..1 Whether the characteristic is an inclusion criterion or exclusion criterion -->
  <definitionReference><!-- I 0..1 Reference(Evidence|EvidenceVariable|Group) Defines the characteristic (without using type and value) by a Reference --></definitionReference>
  <definitionCanonical><!-- I 0..1 canonical(Evidence|EvidenceVariable) Defines the characteristic (without using type and value) by a Canonical --></definitionCanonical>
  <definitionCodeableConcept><!-- I 0..1 CodeableConcept Defines the characteristic (without using type and value) by a CodeableConcept --></definitionCodeableConcept>
  <definitionExpression><!-- 0..1 Expression Defines the characteristic (without using type and value) by an expression --></definitionExpression>
  <definitionId value="[id]"/><!-- I 0..1 Defines the characteristic (without using type and value) by an id -->
  <definitionByTypeAndValue>  <!-- I 0..1 Defines the characteristic using type and value -->
   <type><!-- 1..1 CodeableConcept Expresses the type of characteristic  --></type>
   <method><!-- 0..* CodeableConcept Method for how the characteristic value was determined --></method>
   <device><!-- 0..1 Reference(Device|DeviceMetric) Device used for determining characteristic --></device>
   <value[x]><!-- 1..1 CodeableConcept|boolean|Quantity|Range|Reference|id Defines the characteristic when coupled with characteristic.type --></value[x]>
   <offset><!-- 0..1 CodeableConcept Reference point for valueQuantity or valueRange --></offset>
  </definitionByTypeAndValue>
  <definitionByCombination>  <!-- I 0..1 Used to specify how two or more characteristics are combined -->
   <code value="[code]"/><!-- 1..1 all-of | any-of | at-least | at-most | statistical | net-effect | dataset -->
   <threshold value="[positiveInt]"/><!-- 0..1 Provides the value of "n" when "at-least" or "at-most" codes are used -->
   <characteristic><!-- 1..* Content as for EvidenceVariable.characteristic A defining factor of the characteristic --></characteristic>
  </definitionByCombination>
  <instances[x]><!-- 0..1 Quantity|Range Number of occurrences meeting the characteristic --></instances[x]>
  <duration[x]><!-- 0..1 Quantity|Range Length of time in which the characteristic is met --></duration[x]>
  <timeFromEvent>  <!-- 0..* Timing in which the characteristic is determined -->
   <description value="[markdown]"/><!-- 0..1 Human readable description -->
   <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
   <event[x]><!-- 0..1 CodeableConcept|Reference|dateTime|id The event used as a base point (reference point) in time --></event[x]>
   <quantity><!-- 0..1 Quantity Used to express the observation at a defined amount of time before or after the event --></quantity>
   <range><!-- 0..1 Range Used to express the observation within a period before and/or after the event --></range>
  </timeFromEvent>

 </characteristic>
 <handling value="[code]"/><!-- 0..1 continuous | dichotomous | ordinal | polychotomous -->
 <category>  <!-- 0..* A grouping for ordinal or polychotomous variables -->
  <name value="[string]"/><!-- 0..1 Description of the grouping -->
  <value[x]><!-- 0..1 CodeableConcept|Quantity|Range Definition of the grouping --></value[x]>
 </category>

</EvidenceVariable>

{
  "resourceType" : "",

  "resourceType" : "EvidenceVariable",

  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "

  "url" : "<uri>", // Canonical identifier for this evidence variable, represented as a URI (globally unique)

  "identifier" : [{ Identifier }], // Additional identifier for the evidence variable
  "version" : "<string>", // Business version of the evidence variable
  "

  // versionAlgorithm[x]: How to compare versions. One of these 2:
  "versionAlgorithmString" : "<string>",
  "versionAlgorithmCoding" : { Coding },
  "name" : "<string>", // I Name for this evidence variable (computer friendly)

  "title" : "<string>", // Name for this evidence variable (human friendly)
  "shortTitle" : "<string>", // Title for use in informal contexts
  "

  "status" : "<code>", // R!  draft | active | retired | unknown
  "
  "

  "experimental" : <boolean>, // For testing purposes, not real usage
  "date" : "<dateTime>", // Date last changed
  "publisher" : "<string>", // Name of the publisher/steward (organization or individual)

  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "description" : "<markdown>", // Natural language description of the evidence variable
  "note" : [{ Annotation }], // Used for footnotes or explanatory notes
  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "
  "
  "
  "
  "
  "

  "purpose" : "<markdown>", // Why this EvidenceVariable is defined
  "copyright" : "<markdown>", // Use and/or publishing restrictions
  "copyrightLabel" : "<string>", // Copyright holder and year(s)
  "approvalDate" : "<date>", // When the resource was approved by publisher
  "lastReviewDate" : "<date>", // When the resource was last reviewed by the publisher
  "effectivePeriod" : { Period }, // When the resource is expected to be used

  "author" : [{ ContactDetail }], // Who authored the content
  "editor" : [{ ContactDetail }], // Who edited the content
  "
  "
  "
  "
  "
    "
    
    " },
    " },
    " },
    " },
    " },
    " },
    "
    "
    
    ">",
    " },
    " },
    " },
    "
    "

  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content
  "relatedArtifact" : [{ RelatedArtifact }], // Additional documentation, citations, etc
  "actual" : <boolean>, // Actual or conceptual
  "characteristic" : [{ // A defining factor of the EvidenceVariable
    "linkId" : "<id>", // Label for internal linking
    "description" : "<markdown>", // Natural language description of the characteristic
    "note" : [{ Annotation }], // Used for footnotes or explanatory notes
    "exclude" : <boolean>, // Whether the characteristic is an inclusion criterion or exclusion criterion
    "definitionReference" : { Reference(Evidence|EvidenceVariable|Group) }, // I Defines the characteristic (without using type and value) by a Reference
    "definitionCanonical" : "<canonical(EvidenceVariable|Evidence)>", // I Defines the characteristic (without using type and value) by a Canonical
    "definitionCodeableConcept" : { CodeableConcept }, // I Defines the characteristic (without using type and value) by a CodeableConcept
    "definitionExpression" : { Expression }, // Defines the characteristic (without using type and value) by an expression
    "definitionId" : "<id>", // I Defines the characteristic (without using type and value) by an id
    "definitionByTypeAndValue" : { // I Defines the characteristic using type and value
      "type" : { CodeableConcept }, // R!  Expresses the type of characteristic 
      "method" : [{ CodeableConcept }], // Method for how the characteristic value was determined
      "device" : { Reference(Device|DeviceMetric) }, // Device used for determining characteristic
      // value[x]: Defines the characteristic when coupled with characteristic.type. One of these 6:

      "valueCodeableConcept" : { CodeableConcept },
      "valueBoolean" : <boolean>,
      "valueQuantity" : { Quantity },
      "valueRange" : { Range },
      "valueReference" : { Reference },
      "valueId" : "<id>",
      "offset" : { CodeableConcept } // Reference point for valueQuantity or valueRange
    },
    "definitionByCombination" : { // I Used to specify how two or more characteristics are combined
      "code" : "<code>", // R!  all-of | any-of | at-least | at-most | statistical | net-effect | dataset
      "threshold" : "<positiveInt>", // Provides the value of "n" when "at-least" or "at-most" codes are used
      "characteristic" : [{ Content as for EvidenceVariable.characteristic }] // R!  A defining factor of the characteristic
    },
    // instances[x]: Number of occurrences meeting the characteristic. One of these 2:

    "instancesQuantity" : { Quantity },
    "instancesRange" : { Range },
    // duration[x]: Length of time in which the characteristic is met. One of these 2:

    "durationQuantity" : { Quantity },
    "durationRange" : { Range },
    "timeFromEvent" : [{ // Timing in which the characteristic is determined
      "description" : "<markdown>", // Human readable description
      "note" : [{ Annotation }], // Used for footnotes or explanatory notes
      // event[x]: The event used as a base point (reference point) in time. One of these 4:

      "eventCodeableConcept" : { CodeableConcept },
      "eventReference" : { Reference },
      "eventDateTime" : "<dateTime>",
      "eventId" : "<id>",
      "quantity" : { Quantity }, // Used to express the observation at a defined amount of time before or after the event
      "range" : { Range } // Used to express the observation within a period before and/or after the event
    }]
  }],
  "handling" : "<code>", // continuous | dichotomous | ordinal | polychotomous
  "category" : [{ // A grouping for ordinal or polychotomous variables
    "name" : "<string>", // Description of the grouping
    // value[x]: Definition of the grouping. One of these 3:

    "valueCodeableConcept" : { CodeableConcept },
    "valueQuantity" : { Quantity },
    "valueRange" : { Range }

  }]
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:;

[ a fhir:EvidenceVariable;

  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
    fhir:
    # . One of these 6
      fhir:) ]
      fhir:) ]
      fhir: ]
      fhir: ]
      fhir: ]
      fhir: ]
    fhir:
    fhir:
    # . One of these 4
      fhir: ]
      fhir: ]
      fhir: ]
      fhir: ]
    fhir:
    fhir:
  ], ...;

  fhir:url [ uri ] ; # 0..1 Canonical identifier for this evidence variable, represented as a URI (globally unique)
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Additional identifier for the evidence variable
  fhir:version [ string ] ; # 0..1 Business version of the evidence variable
  # versionAlgorithm[x] : 0..1 How to compare versions. One of these 2
    fhir:versionAlgorithm [  a fhir:string ; string ]
    fhir:versionAlgorithm [  a fhir:Coding ; Coding ]
  fhir:name [ string ] ; # 0..1 I Name for this evidence variable (computer friendly)
  fhir:title [ string ] ; # 0..1 Name for this evidence variable (human friendly)
  fhir:shortTitle [ string ] ; # 0..1 Title for use in informal contexts
  fhir:status [ code ] ; # 1..1 draft | active | retired | unknown
  fhir:experimental [ boolean ] ; # 0..1 For testing purposes, not real usage
  fhir:date [ dateTime ] ; # 0..1 Date last changed
  fhir:publisher [ string ] ; # 0..1 Name of the publisher/steward (organization or individual)
  fhir:contact  ( [ ContactDetail ] ... ) ; # 0..* Contact details for the publisher
  fhir:description [ markdown ] ; # 0..1 Natural language description of the evidence variable
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
  fhir:useContext  ( [ UsageContext ] ... ) ; # 0..* The context that the content is intended to support
  fhir:purpose [ markdown ] ; # 0..1 Why this EvidenceVariable is defined
  fhir:copyright [ markdown ] ; # 0..1 Use and/or publishing restrictions
  fhir:copyrightLabel [ string ] ; # 0..1 Copyright holder and year(s)
  fhir:approvalDate [ date ] ; # 0..1 When the resource was approved by publisher
  fhir:lastReviewDate [ date ] ; # 0..1 When the resource was last reviewed by the publisher
  fhir:effectivePeriod [ Period ] ; # 0..1 When the resource is expected to be used
  fhir:author  ( [ ContactDetail ] ... ) ; # 0..* Who authored the content
  fhir:editor  ( [ ContactDetail ] ... ) ; # 0..* Who edited the content
  fhir:reviewer  ( [ ContactDetail ] ... ) ; # 0..* Who reviewed the content
  fhir:endorser  ( [ ContactDetail ] ... ) ; # 0..* Who endorsed the content
  fhir:relatedArtifact  ( [ RelatedArtifact ] ... ) ; # 0..* Additional documentation, citations, etc
  fhir:actual [ boolean ] ; # 0..1 Actual or conceptual
  fhir:characteristic ( [ # 0..* A defining factor of the EvidenceVariable
    fhir:linkId [ id ] ; # 0..1 Label for internal linking
    fhir:description [ markdown ] ; # 0..1 Natural language description of the characteristic
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
    fhir:exclude [ boolean ] ; # 0..1 Whether the characteristic is an inclusion criterion or exclusion criterion
    fhir:definitionReference [ Reference(Evidence|EvidenceVariable|Group) ] ; # 0..1 I Defines the characteristic (without using type and value) by a Reference
    fhir:definitionCanonical [ canonical(Evidence|EvidenceVariable) ] ; # 0..1 I Defines the characteristic (without using type and value) by a Canonical
    fhir:definitionCodeableConcept [ CodeableConcept ] ; # 0..1 I Defines the characteristic (without using type and value) by a CodeableConcept
    fhir:definitionExpression [ Expression ] ; # 0..1 Defines the characteristic (without using type and value) by an expression
    fhir:definitionId [ id ] ; # 0..1 I Defines the characteristic (without using type and value) by an id
    fhir:definitionByTypeAndValue [ # 0..1 I Defines the characteristic using type and value
      fhir:type [ CodeableConcept ] ; # 1..1 Expresses the type of characteristic
      fhir:method  ( [ CodeableConcept ] ... ) ; # 0..* Method for how the characteristic value was determined
      fhir:device [ Reference(Device|DeviceMetric) ] ; # 0..1 Device used for determining characteristic
      # value[x] : 1..1 Defines the characteristic when coupled with characteristic.type. One of these 6
        fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
        fhir:value [  a fhir:boolean ; boolean ]
        fhir:value [  a fhir:Quantity ; Quantity ]
        fhir:value [  a fhir:Range ; Range ]
        fhir:value [  a fhir:Reference ; Reference ]
        fhir:value [  a fhir:id ; id ]
      fhir:offset [ CodeableConcept ] ; # 0..1 Reference point for valueQuantity or valueRange
    ] ;
    fhir:definitionByCombination [ # 0..1 I Used to specify how two or more characteristics are combined
      fhir:code [ code ] ; # 1..1 all-of | any-of | at-least | at-most | statistical | net-effect | dataset
      fhir:threshold [ positiveInt ] ; # 0..1 Provides the value of "n" when "at-least" or "at-most" codes are used
      fhir:characteristic  ( [ See EvidenceVariable.characteristic ] ... ) ; # 1..* A defining factor of the characteristic
    ] ;
    # instances[x] : 0..1 Number of occurrences meeting the characteristic. One of these 2
      fhir:instances [  a fhir:Quantity ; Quantity ]
      fhir:instances [  a fhir:Range ; Range ]
    # duration[x] : 0..1 Length of time in which the characteristic is met. One of these 2
      fhir:duration [  a fhir:Quantity ; Quantity ]
      fhir:duration [  a fhir:Range ; Range ]
    fhir:timeFromEvent ( [ # 0..* Timing in which the characteristic is determined
      fhir:description [ markdown ] ; # 0..1 Human readable description
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
      # event[x] : 0..1 The event used as a base point (reference point) in time. One of these 4
        fhir:event [  a fhir:CodeableConcept ; CodeableConcept ]
        fhir:event [  a fhir:Reference ; Reference ]
        fhir:event [  a fhir:dateTime ; dateTime ]
        fhir:event [  a fhir:id ; id ]
      fhir:quantity [ Quantity ] ; # 0..1 Used to express the observation at a defined amount of time before or after the event
      fhir:range [ Range ] ; # 0..1 Used to express the observation within a period before and/or after the event
    ] ... ) ;
  ] ... ) ;
  fhir:handling [ code ] ; # 0..1 continuous | dichotomous | ordinal | polychotomous
  fhir:category ( [ # 0..* A grouping for ordinal or polychotomous variables
    fhir:name [ string ] ; # 0..1 Description of the grouping
    # value[x] : 0..1 Definition of the grouping. One of these 3
      fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:value [  a fhir:Quantity ; Quantity ]
      fhir:value [  a fhir:Range ; Range ]
  ] ... ) ;

]

Changes since R3 from both R4 and R4B

This resource did not exist in Release 2 See the Full Difference for further information

This analysis is available for R4 as XML or JSON and for R4B as XML or JSON .

Name	Flags	Card.	Type	Description & Constraints
EvidenceVariable	I TU		DomainResource	A population, intervention, or exposure definition of an exposure, outcome, or other variable + Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension Interfaces Implemented: MetadataResource
url	Σ C	0..1	uri	Canonical identifier for this evidence variable, represented as a URI (globally unique) + Warning: URL should not contain | or # - these characters make processing canonical references problematic
identifier	Σ	0..*	Identifier	Additional identifier for the evidence variable
version	Σ	0..1	string	Business version of the evidence variable
name versionAlgorithm[x]	Σ I	0..1		How to compare versions Binding: Version Algorithm ( Extensible )
versionAlgorithmString			string
versionAlgorithmCoding		Name for this evidence variable (computer friendly)	Coding
title name	Σ C	0..1	string	Name for this evidence variable (human (computer friendly)
shortTitle title	Σ	0..1	string	Title Name for use in informal contexts this evidence variable (human friendly)
subtitle shortTitle	Σ	0..1	string	Subordinate title of the EvidenceVariable Title for use in informal contexts
status	?! Σ	1..1	code	draft | active | retired | unknown Binding: PublicationStatus ( Required )
date experimental		0..1	boolean	For testing purposes, not real usage
date	Σ	0..1	dateTime	Date last changed
publisher	Σ	0..1	string	Name of the publisher publisher/steward (organization or individual)
contact	Σ	0..*	ContactDetail	Contact details for the publisher
description	Σ	0..1	markdown	Natural language description of the evidence variable
note		0..*	Annotation	Used for footnotes or explanatory notes
useContext	Σ	0..*	UsageContext	The context that the content is intended to support
jurisdiction purpose	Σ	0..1	markdown	Why this EvidenceVariable is defined
copyright		Intended jurisdiction for evidence variable (if applicable) 0..1	markdown )	Use and/or publishing restrictions
copyright copyrightLabel	T	0..1	markdown string	Use and/or publishing restrictions Copyright holder and year(s)
approvalDate		0..1	date	When the evidence variable resource was approved by publisher
lastReviewDate		0..1	date	When the evidence variable resource was last reviewed by the publisher
effectivePeriod		0..1	Period	When the evidence variable resource is expected to be used
topic author		0..*	CodeableConcept ContactDetail	The category of Who authored the EvidenceVariable, such as Education, Treatment, Assessment, etc. content DefinitionTopic ( Example )
author editor		0..*	ContactDetail	Who authored edited the content
editor reviewer		0..*	ContactDetail	Who edited reviewed the content
reviewer endorser		0..*	ContactDetail	Who reviewed endorsed the content
endorser relatedArtifact		0..*	RelatedArtifact	Additional documentation, citations, etc
actual		0..1	boolean	Actual or conceptual
characteristic	Σ C	0..*	ContactDetail BackboneElement	Who endorsed A defining factor of the content EvidenceVariable + Rule: In a characteristic, at most one of these six elements shall be used: definitionReference or definitionCanonical or definitionCodeableConcept or definitionId or definitionByTypeAndValue or definitionByCombination
relatedArtifact linkId		0..1	id	Label for internal linking
description		0..1	markdown	Natural language description of the characteristic
note		0..*	RelatedArtifact Annotation	Additional documentation, citations, etc. Used for footnotes or explanatory notes
type exclude		0..1	boolean	Whether the characteristic is an inclusion criterion or exclusion criterion
definitionReference	Σ C	0..1	Reference ( EvidenceVariable | Group | Evidence )	Defines the characteristic (without using type and value) by a Reference
definitionCanonical	code Σ C	dichotomous | continuous | descriptive 0..1	canonical ( Required EvidenceVariable | Evidence )	Defines the characteristic (without using type and value) by a Canonical
characteristic definitionCodeableConcept	Σ C	1..* 0..1	BackboneElement CodeableConcept	What defines the members of Defines the evidence element characteristic (without using type and value) by a CodeableConcept
description definitionExpression	Σ	0..1	string Expression	Natural language description of Defines the characteristic (without using type and value) by an expression
definition[x] definitionId	Σ C	1..1 0..1	id	What code or expression defines members? Defines the characteristic (without using type and value) by an id
definitionByTypeAndValue definitionReference	Σ C	0..1	Reference ( Group BackboneElement )	Defines the characteristic using type and value
definitionCanonical type	Σ	1..1	CodeableConcept	Expresses the type of characteristic Binding: UsageContextType canonical ( ActivityDefinition Example )
definitionCodeableConcept method		0..*	CodeableConcept	Method for how the characteristic value was determined Binding: Definition Method ( Example )
device		0..1	Reference ( Device | DeviceMetric )	Device used for determining characteristic
value[x]	CodeableConcept Σ	1..1		Defines the characteristic when coupled with characteristic.type
definitionExpression valueCodeableConcept			CodeableConcept	Expression
valueBoolean			boolean
valueQuantity			Quantity
definitionDataRequirement valueRange			Range	DataRequirement
valueReference			Reference ()
definitionTriggerDefinition valueId			id
offset		0..1	CodeableConcept	Reference point for valueQuantity or valueRange Binding: Characteristic Offset ( Example )
usageContext definitionByCombination	C	0..* 0..1	UsageContext BackboneElement	What code/value pairs define members? Used to specify how two or more characteristics are combined
exclude code		1..1	code	all-of | any-of | at-least | at-most | statistical | net-effect | dataset Binding: Characteristic Combination ( Required )
threshold		0..1	positiveInt	Provides the value of "n" when "at-least" or "at-most" codes are used
characteristic		1..*	see characteristic	Whether A defining factor of the characteristic includes or excludes members
participantEffective[x] instances[x]		0..1		What time period do participants cover Number of occurrences meeting the characteristic
participantEffectiveDateTime instancesQuantity			Quantity	dateTime
instancesRange			Range
duration[x]		0..1		Length of time in which the characteristic is met
participantEffectivePeriod durationQuantity			Quantity
durationRange			Range
timeFromEvent		0..*	BackboneElement	Timing in which the characteristic is determined
participantEffectiveDuration description		0..1	markdown	Human readable description Duration
note		0..*	Annotation	Used for footnotes or explanatory notes
event[x]		0..1		The event used as a base point (reference point) in time Binding: Evidence Variable Event ( Example )
participantEffectiveTiming eventCodeableConcept			CodeableConcept	Timing
eventReference			Reference ()
timeFromStart eventDateTime			dateTime
eventId			id
quantity		0..1	Duration Quantity	Used to express the observation at a defined amount of time from study start before or after the event
groupMeasure range		0..1	Range	Used to express the observation within a period before and/or after the event
handling		0..1	code	mean | median | mean-of-mean continuous | mean-of-median dichotomous | median-of-mean ordinal | median-of-median polychotomous GroupMeasure Binding: Evidence Variable Handling ( Required )
category		0..*	BackboneElement	A grouping for ordinal or polychotomous variables
name		0..1	string	Description of the grouping
value[x]		0..1		Definition of the grouping
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueRange			Range
Documentation for this format

See the Extensions for this resource

<

<EvidenceVariable xmlns="http://hl7.org/fhir"> 

 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <

 <url value="[uri]"/><!-- 0..1 Canonical identifier for this evidence variable, represented as a URI (globally unique) -->

 <identifier><!-- 0..* Identifier Additional identifier for the evidence variable --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of the evidence variable -->
 <

 <versionAlgorithm[x]><!-- 0..1 string|Coding How to compare versions --></versionAlgorithm[x]>
 <name value="[string]"/><!-- I 0..1 Name for this evidence variable (computer friendly) -->

 <title value="[string]"/><!-- 0..1 Name for this evidence variable (human friendly) -->
 <shortTitle value="[string]"/><!-- 0..1 Title for use in informal contexts -->
 <

 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <
 <

 <experimental value="[boolean]"/><!-- 0..1 For testing purposes, not real usage -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <publisher value="[string]"/><!-- 0..1 Name of the publisher/steward (organization or individual) -->

 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <description value="[markdown]"/><!-- 0..1 Natural language description of the evidence variable -->
 <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <</jurisdiction>
 <
 <
 <
 <</effectivePeriod>
 <</topic>

 <purpose value="[markdown]"/><!-- 0..1 Why this EvidenceVariable is defined -->
 <copyright value="[markdown]"/><!-- 0..1 Use and/or publishing restrictions -->
 <copyrightLabel value="[string]"/><!-- 0..1 Copyright holder and year(s) -->
 <approvalDate value="[date]"/><!-- 0..1 When the resource was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the resource was last reviewed by the publisher -->
 <effectivePeriod><!-- 0..1 Period When the resource is expected to be used --></effectivePeriod>

 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <</reviewer>
 <</endorser>
 <</relatedArtifact>
 <
 <
  <
  <)|
    </definition[x]>
  <</usageContext>
  <
  <</participantEffective[x]>
  <</timeFromStart>
  <

 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>
 <relatedArtifact><!-- 0..* RelatedArtifact Additional documentation, citations, etc --></relatedArtifact>
 <actual value="[boolean]"/><!-- 0..1 Actual or conceptual -->
 <characteristic>  <!-- 0..* A defining factor of the EvidenceVariable -->
  <linkId value="[id]"/><!-- 0..1 Label for internal linking -->
  <description value="[markdown]"/><!-- 0..1 Natural language description of the characteristic -->
  <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  <exclude value="[boolean]"/><!-- 0..1 Whether the characteristic is an inclusion criterion or exclusion criterion -->
  <definitionReference><!-- I 0..1 Reference(Evidence|EvidenceVariable|Group) Defines the characteristic (without using type and value) by a Reference --></definitionReference>
  <definitionCanonical><!-- I 0..1 canonical(Evidence|EvidenceVariable) Defines the characteristic (without using type and value) by a Canonical --></definitionCanonical>
  <definitionCodeableConcept><!-- I 0..1 CodeableConcept Defines the characteristic (without using type and value) by a CodeableConcept --></definitionCodeableConcept>
  <definitionExpression><!-- 0..1 Expression Defines the characteristic (without using type and value) by an expression --></definitionExpression>
  <definitionId value="[id]"/><!-- I 0..1 Defines the characteristic (without using type and value) by an id -->
  <definitionByTypeAndValue>  <!-- I 0..1 Defines the characteristic using type and value -->
   <type><!-- 1..1 CodeableConcept Expresses the type of characteristic  --></type>
   <method><!-- 0..* CodeableConcept Method for how the characteristic value was determined --></method>
   <device><!-- 0..1 Reference(Device|DeviceMetric) Device used for determining characteristic --></device>
   <value[x]><!-- 1..1 CodeableConcept|boolean|Quantity|Range|Reference|id Defines the characteristic when coupled with characteristic.type --></value[x]>
   <offset><!-- 0..1 CodeableConcept Reference point for valueQuantity or valueRange --></offset>
  </definitionByTypeAndValue>
  <definitionByCombination>  <!-- I 0..1 Used to specify how two or more characteristics are combined -->
   <code value="[code]"/><!-- 1..1 all-of | any-of | at-least | at-most | statistical | net-effect | dataset -->
   <threshold value="[positiveInt]"/><!-- 0..1 Provides the value of "n" when "at-least" or "at-most" codes are used -->
   <characteristic><!-- 1..* Content as for EvidenceVariable.characteristic A defining factor of the characteristic --></characteristic>
  </definitionByCombination>
  <instances[x]><!-- 0..1 Quantity|Range Number of occurrences meeting the characteristic --></instances[x]>
  <duration[x]><!-- 0..1 Quantity|Range Length of time in which the characteristic is met --></duration[x]>
  <timeFromEvent>  <!-- 0..* Timing in which the characteristic is determined -->
   <description value="[markdown]"/><!-- 0..1 Human readable description -->
   <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
   <event[x]><!-- 0..1 CodeableConcept|Reference|dateTime|id The event used as a base point (reference point) in time --></event[x]>
   <quantity><!-- 0..1 Quantity Used to express the observation at a defined amount of time before or after the event --></quantity>
   <range><!-- 0..1 Range Used to express the observation within a period before and/or after the event --></range>
  </timeFromEvent>

 </characteristic>
 <handling value="[code]"/><!-- 0..1 continuous | dichotomous | ordinal | polychotomous -->
 <category>  <!-- 0..* A grouping for ordinal or polychotomous variables -->
  <name value="[string]"/><!-- 0..1 Description of the grouping -->
  <value[x]><!-- 0..1 CodeableConcept|Quantity|Range Definition of the grouping --></value[x]>
 </category>

</EvidenceVariable>

{
  "resourceType" : "",

  "resourceType" : "EvidenceVariable",

  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "

  "url" : "<uri>", // Canonical identifier for this evidence variable, represented as a URI (globally unique)

  "identifier" : [{ Identifier }], // Additional identifier for the evidence variable
  "version" : "<string>", // Business version of the evidence variable
  "

  // versionAlgorithm[x]: How to compare versions. One of these 2:
  "versionAlgorithmString" : "<string>",
  "versionAlgorithmCoding" : { Coding },
  "name" : "<string>", // I Name for this evidence variable (computer friendly)

  "title" : "<string>", // Name for this evidence variable (human friendly)
  "shortTitle" : "<string>", // Title for use in informal contexts
  "

  "status" : "<code>", // R!  draft | active | retired | unknown
  "
  "

  "experimental" : <boolean>, // For testing purposes, not real usage
  "date" : "<dateTime>", // Date last changed
  "publisher" : "<string>", // Name of the publisher/steward (organization or individual)

  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "description" : "<markdown>", // Natural language description of the evidence variable
  "note" : [{ Annotation }], // Used for footnotes or explanatory notes
  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "
  "
  "
  "
  "
  "

  "purpose" : "<markdown>", // Why this EvidenceVariable is defined
  "copyright" : "<markdown>", // Use and/or publishing restrictions
  "copyrightLabel" : "<string>", // Copyright holder and year(s)
  "approvalDate" : "<date>", // When the resource was approved by publisher
  "lastReviewDate" : "<date>", // When the resource was last reviewed by the publisher
  "effectivePeriod" : { Period }, // When the resource is expected to be used

  "author" : [{ ContactDetail }], // Who authored the content
  "editor" : [{ ContactDetail }], // Who edited the content
  "
  "
  "
  "
  "
    "
    
    " },
    " },
    " },
    " },
    " },
    " },
    "
    "
    
    ">",
    " },
    " },
    " },
    "
    "

  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content
  "relatedArtifact" : [{ RelatedArtifact }], // Additional documentation, citations, etc
  "actual" : <boolean>, // Actual or conceptual
  "characteristic" : [{ // A defining factor of the EvidenceVariable
    "linkId" : "<id>", // Label for internal linking
    "description" : "<markdown>", // Natural language description of the characteristic
    "note" : [{ Annotation }], // Used for footnotes or explanatory notes
    "exclude" : <boolean>, // Whether the characteristic is an inclusion criterion or exclusion criterion
    "definitionReference" : { Reference(Evidence|EvidenceVariable|Group) }, // I Defines the characteristic (without using type and value) by a Reference
    "definitionCanonical" : "<canonical(EvidenceVariable|Evidence)>", // I Defines the characteristic (without using type and value) by a Canonical
    "definitionCodeableConcept" : { CodeableConcept }, // I Defines the characteristic (without using type and value) by a CodeableConcept
    "definitionExpression" : { Expression }, // Defines the characteristic (without using type and value) by an expression
    "definitionId" : "<id>", // I Defines the characteristic (without using type and value) by an id
    "definitionByTypeAndValue" : { // I Defines the characteristic using type and value
      "type" : { CodeableConcept }, // R!  Expresses the type of characteristic 
      "method" : [{ CodeableConcept }], // Method for how the characteristic value was determined
      "device" : { Reference(Device|DeviceMetric) }, // Device used for determining characteristic
      // value[x]: Defines the characteristic when coupled with characteristic.type. One of these 6:

      "valueCodeableConcept" : { CodeableConcept },
      "valueBoolean" : <boolean>,
      "valueQuantity" : { Quantity },
      "valueRange" : { Range },
      "valueReference" : { Reference },
      "valueId" : "<id>",
      "offset" : { CodeableConcept } // Reference point for valueQuantity or valueRange
    },
    "definitionByCombination" : { // I Used to specify how two or more characteristics are combined
      "code" : "<code>", // R!  all-of | any-of | at-least | at-most | statistical | net-effect | dataset
      "threshold" : "<positiveInt>", // Provides the value of "n" when "at-least" or "at-most" codes are used
      "characteristic" : [{ Content as for EvidenceVariable.characteristic }] // R!  A defining factor of the characteristic
    },
    // instances[x]: Number of occurrences meeting the characteristic. One of these 2:

    "instancesQuantity" : { Quantity },
    "instancesRange" : { Range },
    // duration[x]: Length of time in which the characteristic is met. One of these 2:

    "durationQuantity" : { Quantity },
    "durationRange" : { Range },
    "timeFromEvent" : [{ // Timing in which the characteristic is determined
      "description" : "<markdown>", // Human readable description
      "note" : [{ Annotation }], // Used for footnotes or explanatory notes
      // event[x]: The event used as a base point (reference point) in time. One of these 4:

      "eventCodeableConcept" : { CodeableConcept },
      "eventReference" : { Reference },
      "eventDateTime" : "<dateTime>",
      "eventId" : "<id>",
      "quantity" : { Quantity }, // Used to express the observation at a defined amount of time before or after the event
      "range" : { Range } // Used to express the observation within a period before and/or after the event
    }]
  }],
  "handling" : "<code>", // continuous | dichotomous | ordinal | polychotomous
  "category" : [{ // A grouping for ordinal or polychotomous variables
    "name" : "<string>", // Description of the grouping
    // value[x]: Definition of the grouping. One of these 3:

    "valueCodeableConcept" : { CodeableConcept },
    "valueQuantity" : { Quantity },
    "valueRange" : { Range }

  }]
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:;

[ a fhir:EvidenceVariable;

  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
  fhir:
    fhir:
    # . One of these 6
      fhir:) ]
      fhir:) ]
      fhir: ]
      fhir: ]
      fhir: ]
      fhir: ]
    fhir:
    fhir:
    # . One of these 4
      fhir: ]
      fhir: ]
      fhir: ]
      fhir: ]
    fhir:
    fhir:
  ], ...;

  fhir:url [ uri ] ; # 0..1 Canonical identifier for this evidence variable, represented as a URI (globally unique)
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Additional identifier for the evidence variable
  fhir:version [ string ] ; # 0..1 Business version of the evidence variable
  # versionAlgorithm[x] : 0..1 How to compare versions. One of these 2
    fhir:versionAlgorithm [  a fhir:string ; string ]
    fhir:versionAlgorithm [  a fhir:Coding ; Coding ]
  fhir:name [ string ] ; # 0..1 I Name for this evidence variable (computer friendly)
  fhir:title [ string ] ; # 0..1 Name for this evidence variable (human friendly)
  fhir:shortTitle [ string ] ; # 0..1 Title for use in informal contexts
  fhir:status [ code ] ; # 1..1 draft | active | retired | unknown
  fhir:experimental [ boolean ] ; # 0..1 For testing purposes, not real usage
  fhir:date [ dateTime ] ; # 0..1 Date last changed
  fhir:publisher [ string ] ; # 0..1 Name of the publisher/steward (organization or individual)
  fhir:contact  ( [ ContactDetail ] ... ) ; # 0..* Contact details for the publisher
  fhir:description [ markdown ] ; # 0..1 Natural language description of the evidence variable
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
  fhir:useContext  ( [ UsageContext ] ... ) ; # 0..* The context that the content is intended to support
  fhir:purpose [ markdown ] ; # 0..1 Why this EvidenceVariable is defined
  fhir:copyright [ markdown ] ; # 0..1 Use and/or publishing restrictions
  fhir:copyrightLabel [ string ] ; # 0..1 Copyright holder and year(s)
  fhir:approvalDate [ date ] ; # 0..1 When the resource was approved by publisher
  fhir:lastReviewDate [ date ] ; # 0..1 When the resource was last reviewed by the publisher
  fhir:effectivePeriod [ Period ] ; # 0..1 When the resource is expected to be used
  fhir:author  ( [ ContactDetail ] ... ) ; # 0..* Who authored the content
  fhir:editor  ( [ ContactDetail ] ... ) ; # 0..* Who edited the content
  fhir:reviewer  ( [ ContactDetail ] ... ) ; # 0..* Who reviewed the content
  fhir:endorser  ( [ ContactDetail ] ... ) ; # 0..* Who endorsed the content
  fhir:relatedArtifact  ( [ RelatedArtifact ] ... ) ; # 0..* Additional documentation, citations, etc
  fhir:actual [ boolean ] ; # 0..1 Actual or conceptual
  fhir:characteristic ( [ # 0..* A defining factor of the EvidenceVariable
    fhir:linkId [ id ] ; # 0..1 Label for internal linking
    fhir:description [ markdown ] ; # 0..1 Natural language description of the characteristic
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
    fhir:exclude [ boolean ] ; # 0..1 Whether the characteristic is an inclusion criterion or exclusion criterion
    fhir:definitionReference [ Reference(Evidence|EvidenceVariable|Group) ] ; # 0..1 I Defines the characteristic (without using type and value) by a Reference
    fhir:definitionCanonical [ canonical(Evidence|EvidenceVariable) ] ; # 0..1 I Defines the characteristic (without using type and value) by a Canonical
    fhir:definitionCodeableConcept [ CodeableConcept ] ; # 0..1 I Defines the characteristic (without using type and value) by a CodeableConcept
    fhir:definitionExpression [ Expression ] ; # 0..1 Defines the characteristic (without using type and value) by an expression
    fhir:definitionId [ id ] ; # 0..1 I Defines the characteristic (without using type and value) by an id
    fhir:definitionByTypeAndValue [ # 0..1 I Defines the characteristic using type and value
      fhir:type [ CodeableConcept ] ; # 1..1 Expresses the type of characteristic
      fhir:method  ( [ CodeableConcept ] ... ) ; # 0..* Method for how the characteristic value was determined
      fhir:device [ Reference(Device|DeviceMetric) ] ; # 0..1 Device used for determining characteristic
      # value[x] : 1..1 Defines the characteristic when coupled with characteristic.type. One of these 6
        fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
        fhir:value [  a fhir:boolean ; boolean ]
        fhir:value [  a fhir:Quantity ; Quantity ]
        fhir:value [  a fhir:Range ; Range ]
        fhir:value [  a fhir:Reference ; Reference ]
        fhir:value [  a fhir:id ; id ]
      fhir:offset [ CodeableConcept ] ; # 0..1 Reference point for valueQuantity or valueRange
    ] ;
    fhir:definitionByCombination [ # 0..1 I Used to specify how two or more characteristics are combined
      fhir:code [ code ] ; # 1..1 all-of | any-of | at-least | at-most | statistical | net-effect | dataset
      fhir:threshold [ positiveInt ] ; # 0..1 Provides the value of "n" when "at-least" or "at-most" codes are used
      fhir:characteristic  ( [ See EvidenceVariable.characteristic ] ... ) ; # 1..* A defining factor of the characteristic
    ] ;
    # instances[x] : 0..1 Number of occurrences meeting the characteristic. One of these 2
      fhir:instances [  a fhir:Quantity ; Quantity ]
      fhir:instances [  a fhir:Range ; Range ]
    # duration[x] : 0..1 Length of time in which the characteristic is met. One of these 2
      fhir:duration [  a fhir:Quantity ; Quantity ]
      fhir:duration [  a fhir:Range ; Range ]
    fhir:timeFromEvent ( [ # 0..* Timing in which the characteristic is determined
      fhir:description [ markdown ] ; # 0..1 Human readable description
      fhir:note  ( [ Annotation ] ... ) ; # 0..* Used for footnotes or explanatory notes
      # event[x] : 0..1 The event used as a base point (reference point) in time. One of these 4
        fhir:event [  a fhir:CodeableConcept ; CodeableConcept ]
        fhir:event [  a fhir:Reference ; Reference ]
        fhir:event [  a fhir:dateTime ; dateTime ]
        fhir:event [  a fhir:id ; id ]
      fhir:quantity [ Quantity ] ; # 0..1 Used to express the observation at a defined amount of time before or after the event
      fhir:range [ Range ] ; # 0..1 Used to express the observation within a period before and/or after the event
    ] ... ) ;
  ] ... ) ;
  fhir:handling [ code ] ; # 0..1 continuous | dichotomous | ordinal | polychotomous
  fhir:category ( [ # 0..* A grouping for ordinal or polychotomous variables
    fhir:name [ string ] ; # 0..1 Description of the grouping
    # value[x] : 0..1 Definition of the grouping. One of these 3
      fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:value [  a fhir:Quantity ; Quantity ]
      fhir:value [  a fhir:Range ; Range ]
  ] ... ) ;

]

Changes since Release 3 from both R4 and R4B