Release 4B 5

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Evidence-example-stroke-alteplase-fatalICH.xml

Example Evidence/example-stroke-alteplase-fatalICH (XML)

Clinical Decision Support Work Group Maturity Level : N/A Standards Status : Informative Compartments : Not linked to any No defined compartments

Raw XML ( canonical form + also see XML Format Specification )

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Risk of fatal ICH with alteplase for stroke (id = "example-stroke-alteplase-fatalICH") 

<?xml version="1.0" encoding="UTF-8"?>


  
  
    
    
      
        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate risk estimate.
      
  
  
  
  
  
  
    
      
      
    
    
      
    
  
  
    
      
      
      
    
    
      
      
    
  
  
  
  
  Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis
     with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data
     from randomised trials.
  Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis
     Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on
     the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis
     of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35
     PMID 25106063
  
  
  2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients
   with acute ischemic stroke
  
    
      
        
        
        
      
    
    
      
      
      
    
    
      
      
      
    
  
  
    
      
        
        
        
      
    
    
      
      
      
    
    
      
      
      
    
  
  
    
      
        
        
        
      
    
    
      
      
      
    
    
      
      
      
    
  
  
    
      
      
      
    
  
  
    
      
      
      
    
  
  
    
      
        
        
        
      
    
    
      
    
    
    
      
      
    
  

<Evidence xmlns="http://hl7.org/fhir">
  <id value="example-stroke-alteplase-fatalICH"/> 
  <text> 
    <status value="generated"/> 
    <div xmlns="http://www.w3.org/1999/xhtml">
      
      <p> 
        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate
         risk estimate.
      </p> 
  
    </div>   </text>   <url value="http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"/>   <identifier>     <system value="urn:ietf:rfc:3986"/>     <value value="urn:oid:2.16.840.1.113883.4.642.10.1"/>   </identifier>   <name value="RiskOfFatalICHWithAlteplaseForStroke"/>   <title value="Risk of fatal ICH with alteplase for stroke"/>   <status value="draft"/>   <relatedArtifact>     <type value="citation"/>     <label value="Emberson 2014"/>     <display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous

     thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual
     patient data from randomised trials."/> 
    <citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis

     Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity
     on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke:
     a meta-analysis of individual patient data from randomised trials. Lancet 2014
     Nov 29;384(9958):1929-35 PMID 25106063"/> 
    <document>       <url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/>     </document>   </relatedArtifact>   <description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in

   patients with acute ischemic stroke"/> 
  <variableDefinition>     <variableRole>       <coding>         <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>         <code value="population"/>         <display value="population"/>       </coding>     </variableRole>     <observed>       <reference value="Group/AcuteIschemicStroke"/>       <type value="Group"/>       <display value="adults with acute ischemic stroke"/>     </observed>     <intended>       <reference value="Group/AcuteIschemicStroke"/>       <type value="Group"/>       <display value="adults with acute ischemic stroke"/>     </intended>   </variableDefinition>   <variableDefinition>     <variableRole>       <coding>         <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>         <code value="population"/>         <display value="population"/>       </coding>     </variableRole>     <observed>       <reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/>       <type value="Group"/>       <display value="Emberson 2014 IPD-MA Alteplase Cohort"/>     </observed>     <intended>       <reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/>       <type value="Group"/>       <display value="adults with acute ischemic stroke treated with alteplase"/>     </intended>   </variableDefinition>   <variableDefinition>     <variableRole>       <coding>         <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>         <code value="measuredVariable"/>         <display value="measured variable"/>       </coding>     </variableRole>     <observed>       <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/>       <type value="EvidenceVariable"/>       <display value="fatal ICH"/>     </observed>     <intended>       <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/>       <type value="EvidenceVariable"/>       <display value="fatal ICH"/>     </intended>   </variableDefinition>   <synthesisType>     <coding>       <system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>       <code value="IPD-MA"/>       <display value="individual patient data meta-analysis"/>     </coding>   </synthesisType>   <studyDesign>     <coding>       <system value="http://hl7.org/fhir/study-design"/>       <code value="SEVCO:01003"/>       <display value="randomized assignment"/>     </coding>   </studyDesign>   <statistic>     <statisticType>       <coding>         <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/>         <code value="C44256"/>         <display value="Proportion"/>       </coding>     </statisticType>     <quantity>       <value value="0.026835741669"/>     </quantity>     <numberOfEvents value="91"/>     <sampleSize>       <numberOfStudies value="9"/>       <numberOfParticipants value="3391"/>     </sampleSize>   </statistic> 


</

Evidence

>

Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.