Drug-drug interaction between prescription and medication statement

@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/DetectedIssue/ddi> a fhir:DetectedIssue;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "ddi"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <p><b>Severity: High</b> - Risk of internal bleeding</p>\n      <p>Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding.</p>\n      <ul>\n        <li><a href=\"MedicationStatement/tylenol\">500 mg Acetaminophen tablet 1/day, PRN since 2010</a></li>\n        <li><a href=\"MedicationRequest/warfarin\">Warfarin 1 MG TAB prescribed Jan. 5, 2014</a></li>\n      </ul>\n      <p>Mitigation: Jan 5, 2014 by Dr. Adam Careful: </p>\n      <p>Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring</p>\n    </div>"
  ];
  fhir:DetectedIssue.status [ fhir:value "final"];
  fhir:DetectedIssue.code [
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v3-ActCode" ];
       fhir:Coding.code [ fhir:value "DRG" ];
       fhir:Coding.display [ fhir:value "Drug Interaction Alert" ]
     ]
  ];
  fhir:DetectedIssue.severity [ fhir:value "high"];
  fhir:DetectedIssue.identifiedDateTime [ fhir:value "2014-01-05"^^xsd:date];
  fhir:DetectedIssue.author [
     fhir:link <http://hl7.org/fhir/Device/software>;
     fhir:Reference.reference [ fhir:value "Device/software" ]
  ];
  fhir:DetectedIssue.implicated [
     fhir:index 0;
     fhir:link <http://hl7.org/fhir/MedicationStatement/example001>;
     fhir:Reference.reference [ fhir:value "MedicationStatement/example001" ];
     fhir:Reference.display [ fhir:value "500 mg Acetaminophen tablet 1/day, PRN since 2010" ]
  ], [
     fhir:index 1;
     fhir:link <http://hl7.org/fhir/MedicationRequest/medrx0331>;
     fhir:Reference.reference [ fhir:value "MedicationRequest/medrx0331" ];
     fhir:Reference.display [ fhir:value "Warfarin 1 MG TAB prescribed Jan. 15, 2015" ]
  ];
  fhir:DetectedIssue.detail [ fhir:value "Risk of internal bleeding.  Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding."];
  fhir:DetectedIssue.mitigation [
     fhir:index 0;
     fhir:DetectedIssue.mitigation.action [
       fhir:CodeableConcept.coding [
         fhir:index 0;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v3-ActCode" ];
         fhir:Coding.code [ fhir:value "13" ];
         fhir:Coding.display [ fhir:value "Stopped Concurrent Therapy" ]
       ];
       fhir:CodeableConcept.text [ fhir:value "Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring" ]
     ];
     fhir:DetectedIssue.mitigation.date [ fhir:value "2014-01-05"^^xsd:date ];
     fhir:DetectedIssue.mitigation.author [
       fhir:link <http://hl7.org/fhir/Practitioner/example>;
       fhir:Reference.reference [ fhir:value "Practitioner/example" ];
       fhir:Reference.display [ fhir:value "Dr. Adam Careful" ]

[a fhir:DetectedIssue ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "ddi"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <p><b>Severity: High</b> - Risk of internal bleeding</p>\n      <p>Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding.</p>\n      <ul>\n        <li><a href=\"MedicationStatement/tylenol\">500 mg Acetaminophen tablet 1/day, PRN since 2010</a></li>\n        <li><a href=\"MedicationRequest/warfarin\">Warfarin 1 MG TAB prescribed Jan. 5, 2014</a></li>\n      </ul>\n      <p>Mitigation: Jan 5, 2014 by Dr. Adam Careful: </p>\n      <p>Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring</p>\n    </div>"
  ] ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "DRG" ] ;
       fhir:display [ fhir:v "Drug Interaction Alert" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "DRG" ] ;
       fhir:display [ fhir:v "Drug Interaction Alert" ]
     ] )
  ] ; # 
  fhir:severity [ fhir:v "high"] ; # 
  fhir:subject [
     fhir:reference [ fhir:v "Device/example" ]
  ] ; # 
  fhir:identified [ fhir:v "2014-01-05"^^xsd:date] ; # 
  fhir:implicated ( [
     fhir:reference [ fhir:v "MedicationStatement/example001" ] ;
     fhir:display [ fhir:v "500 mg Acetaminophen tablet 1/day, PRN since 2010" ]
  ] [
     fhir:reference [ fhir:v "MedicationRequest/medrx0331" ] ;
     fhir:display [ fhir:v "Warfarin 1 MG TAB prescribed Jan. 15, 2015" ]
  ] ) ; # 
  fhir:detail [ fhir:v "Risk of internal bleeding.  Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding."] ; # 
  fhir:mitigation ( [
     fhir:action [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "13" ] ;
         fhir:display [ fhir:v "Stopped Concurrent Therapy" ]
       ] ) ;
       fhir:text [ fhir:v "Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring" ]
     ] ;
     fhir:date [ fhir:v "2014-01-05"^^xsd:date ] ;
     fhir:author [
       fhir:reference [ fhir:v "Practitioner/example" ] ;
       fhir:display [ fhir:v "Dr. Adam Careful" ]

     ]
  ] .

<http://hl7.org/fhir/Device/software> a fhir:Device .

<http://hl7.org/fhir/MedicationStatement/example001> a fhir:MedicationStatement .

<http://hl7.org/fhir/MedicationRequest/medrx0331> a fhir:MedicationRequest .

<http://hl7.org/fhir/Practitioner/example> a fhir:Practitioner .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/DetectedIssue/ddi.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl;
  owl:versionIRI <http://build.fhir.org/DetectedIssue/ddi.ttl> .

  ] )] . # 


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