Medication
Definition
This
page
is
part
of
the
FHIR
Specification
(v5.0.0:
R5
-
STU
v6.0.0-ballot2:
Release
6
Ballot
(2nd
Draft)
(see
Ballot
Notes
).
This
is
the
The
current
published
version
in
it's
permanent
home
(it
will
always
be
available
at
this
URL).
is
5.0.0
.
For
a
full
list
of
available
versions,
see
the
Directory
of
published
versions
.
Page
versions:
R5
R4
|
Biomedical
Research
and
Regulation
Work
Group
|
Maturity Level : 0 | Trial Use | Security Category : Anonymous | Compartments : No defined compartments |
A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators.
For an overview of this resource and others in the Medication Definition domain, also see the module page
Structure
| Name | Flags | Card. | Type |
Description
&
Constraints
|
|---|---|---|---|---|
SubstanceProtein
|
TU | DomainResource |
A
SubstanceProtein
is
defined
as
a
single
unit
of
a
linear
amino
acid
sequence,
or
a
combination
of
subunits
that
are
either
covalently
linked
or
have
a
defined
invariant
stoichiometric
relationship.
This
includes
all
synthetic,
recombinant
and
purified
SubstanceProteins
of
defined
sequence,
whether
the
use
is
therapeutic
or
prophylactic.
This
set
of
elements
will
be
used
to
describe
albumins,
coagulation
factors,
cytokines,
growth
factors,
peptide/SubstanceProtein
hormones,
enzymes,
toxins,
toxoids,
recombinant
vaccines,
and
immunomodulators
Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension |
|
sequenceType
|
Σ | 0..1 | CodeableConcept |
The
SubstanceProtein
descriptive
elements
will
only
be
used
when
a
complete
or
partial
amino
acid
sequence
is
available
or
derivable
from
a
nucleic
acid
sequence
|
numberOfSubunits
|
Σ | 0..1 | integer |
Number
of
linear
sequences
of
amino
acids
linked
through
peptide
bonds.
The
number
of
subunits
constituting
the
SubstanceProtein
shall
be
described.
It
is
possible
that
the
number
of
subunits
can
be
variable
|
|
disulfideLinkage
|
Σ | 0..* | string |
The
disulphide
bond
between
two
cysteine
residues
either
on
the
same
subunit
or
on
two
different
subunits
shall
be
described.
The
position
of
the
disulfide
bonds
in
the
SubstanceProtein
shall
be
listed
in
increasing
order
of
subunit
number
and
position
within
subunit
followed
by
the
abbreviation
of
the
amino
acids
involved.
The
disulfide
linkage
positions
shall
actually
contain
the
amino
acid
Cysteine
at
the
respective
positions
|
subunit
|
Σ | 0..* | BackboneElement |
This
subclause
refers
to
the
description
of
each
subunit
constituting
the
SubstanceProtein.
A
subunit
is
a
linear
sequence
of
amino
acids
linked
through
peptide
bonds.
The
Subunit
information
shall
be
provided
when
the
finished
SubstanceProtein
is
a
complex
of
multiple
sequences;
subunits
are
not
used
to
delineate
domains
within
a
single
sequence.
Subunits
are
listed
in
order
of
decreasing
length;
sequences
of
the
same
length
will
be
ordered
by
decreasing
molecular
weight;
subunits
that
have
identical
sequences
will
be
repeated
multiple
times
|
subunit
|
Σ | 0..1 | integer |
Index
of
primary
sequences
of
amino
acids
linked
through
peptide
bonds
in
order
of
decreasing
length.
Sequences
of
the
same
length
will
be
ordered
by
molecular
weight.
Subunits
that
have
identical
sequences
will
be
repeated
and
have
sequential
subscripts
|
|
sequence
|
Σ | 0..1 | string |
The
sequence
information
shall
be
provided
enumerating
the
amino
acids
from
N-
to
C-terminal
end
using
standard
single-letter
amino
acid
codes.
Uppercase
shall
be
used
for
L-amino
acids
and
lowercase
for
D-amino
acids.
Transcribed
SubstanceProteins
will
always
be
described
using
the
translated
sequence;
for
synthetic
peptide
containing
amino
acids
that
are
not
represented
with
a
single
letter
code
an
X
should
be
used
within
the
sequence.
The
modified
amino
acids
will
be
distinguished
by
their
position
in
the
sequence
|
|
length
|
Σ | 0..1 | integer |
Length
of
linear
sequences
of
amino
acids
contained
in
the
subunit
|
|
sequenceAttachment
|
Σ | 0..1 | Attachment |
The
sequence
information
shall
be
provided
enumerating
the
amino
acids
from
N-
to
C-terminal
end
using
standard
single-letter
amino
acid
codes.
Uppercase
shall
be
used
for
L-amino
acids
and
lowercase
for
D-amino
acids.
Transcribed
SubstanceProteins
will
always
be
described
using
the
translated
sequence;
for
synthetic
peptide
containing
amino
acids
that
are
not
represented
with
a
single
letter
code
an
X
should
be
used
within
the
sequence.
The
modified
amino
acids
will
be
distinguished
by
their
position
in
the
sequence
|
|
nTerminalModificationId
|
Σ | 0..1 | Identifier |
Unique
identifier
for
molecular
fragment
modification
based
on
the
ISO
11238
Substance
ID
|
|
nTerminalModification
|
Σ | 0..1 | string |
The
name
of
the
fragment
modified
at
the
N-terminal
of
the
SubstanceProtein
shall
be
specified
|
|
cTerminalModificationId
|
Σ | 0..1 | Identifier |
Unique
identifier
for
molecular
fragment
modification
based
on
the
ISO
11238
Substance
ID
|
cTerminalModification
|
Σ | 0..1 | string |
The
modification
at
the
C-terminal
shall
be
specified
|
|
Documentation
for
this
format
|
||||
See the Extensions for this resource
UML Diagram ( Legend )
XML Template
<SubstanceProtein xmlns="http://hl7.org/fhir"><!-- from Resource: id, meta, implicitRules, and language --> <!-- from DomainResource: text, contained, extension, and modifierExtension --> <sequenceType><!-- 0..1 CodeableConcept The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence --></sequenceType> <numberOfSubunits value="[integer]"/><!-- 0..1 Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable --> <disulfideLinkage value="[string]"/><!-- 0..* The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions --> <subunit> <!-- 0..* This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times --> <subunit value="[integer]"/><!-- 0..1 Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts --> <sequence value="[string]"/><!-- 0..1 The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence --> <length value="[integer]"/><!-- 0..1 Length of linear sequences of amino acids contained in the subunit --> <sequenceAttachment><!-- 0..1 Attachment The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence --></sequenceAttachment> <nTerminalModificationId><!-- 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID --></nTerminalModificationId> <nTerminalModification value="[string]"/><!-- 0..1 The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified --> <cTerminalModificationId><!-- 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID --></cTerminalModificationId> <cTerminalModification value="[string]"/><!-- 0..1 The modification at the C-terminal shall be specified --> </subunit> </SubstanceProtein>
JSON Template
{
"resourceType" : "SubstanceProtein",
// from Resource: id, meta, implicitRules, and language
// from DomainResource: text, contained, extension, and modifierExtension
"sequenceType" : { CodeableConcept }, // The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
"numberOfSubunits" : <integer>, // Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
"disulfideLinkage" : ["<string>"], // The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
"subunit" : [{ // This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times
"subunit" : <integer>, // Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
"sequence" : "<string>", // The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
"length" : <integer>, // Length of linear sequences of amino acids contained in the subunit
"sequenceAttachment" : { Attachment }, // The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
"nTerminalModificationId" : { Identifier }, // Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
"nTerminalModification" : "<string>", // The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
"cTerminalModificationId" : { Identifier }, // Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
"cTerminalModification" : "<string>" // The modification at the C-terminal shall be specified
}]
}
Turtle Template
@prefix fhir: <http://hl7.org/fhir/> .
Changes from both R4 and R4B
| SubstanceProtein |
|
See the Full Difference for further information
This analysis is available for R4 as XML or JSON and for R4B as XML or JSON .
Structure
| Name | Flags | Card. | Type |
Description
&
Constraints
|
|---|---|---|---|---|
|
SubstanceProtein
|
TU | DomainResource |
A
SubstanceProtein
is
defined
as
a
single
unit
of
a
linear
amino
acid
sequence,
or
a
combination
of
subunits
that
are
either
covalently
linked
or
have
a
defined
invariant
stoichiometric
relationship.
This
includes
all
synthetic,
recombinant
and
purified
SubstanceProteins
of
defined
sequence,
whether
the
use
is
therapeutic
or
prophylactic.
This
set
of
elements
will
be
used
to
describe
albumins,
coagulation
factors,
cytokines,
growth
factors,
peptide/SubstanceProtein
hormones,
enzymes,
toxins,
toxoids,
recombinant
vaccines,
and
immunomodulators
Elements defined in Ancestors: id , meta , implicitRules , language , text , contained , extension , modifierExtension |
|
|
sequenceType
|
Σ | 0..1 | CodeableConcept |
The
SubstanceProtein
descriptive
elements
will
only
be
used
when
a
complete
or
partial
amino
acid
sequence
is
available
or
derivable
from
a
nucleic
acid
sequence
|
|
numberOfSubunits
|
Σ | 0..1 | integer |
Number
of
linear
sequences
of
amino
acids
linked
through
peptide
bonds.
The
number
of
subunits
constituting
the
SubstanceProtein
shall
be
described.
It
is
possible
that
the
number
of
subunits
can
be
variable
|
|
disulfideLinkage
|
Σ | 0..* | string |
The
disulphide
bond
between
two
cysteine
residues
either
on
the
same
subunit
or
on
two
different
subunits
shall
be
described.
The
position
of
the
disulfide
bonds
in
the
SubstanceProtein
shall
be
listed
in
increasing
order
of
subunit
number
and
position
within
subunit
followed
by
the
abbreviation
of
the
amino
acids
involved.
The
disulfide
linkage
positions
shall
actually
contain
the
amino
acid
Cysteine
at
the
respective
positions
|
|
subunit
|
Σ | 0..* | BackboneElement |
This
subclause
refers
to
the
description
of
each
subunit
constituting
the
SubstanceProtein.
A
subunit
is
a
linear
sequence
of
amino
acids
linked
through
peptide
bonds.
The
Subunit
information
shall
be
provided
when
the
finished
SubstanceProtein
is
a
complex
of
multiple
sequences;
subunits
are
not
used
to
delineate
domains
within
a
single
sequence.
Subunits
are
listed
in
order
of
decreasing
length;
sequences
of
the
same
length
will
be
ordered
by
decreasing
molecular
weight;
subunits
that
have
identical
sequences
will
be
repeated
multiple
times
|
|
subunit
|
Σ | 0..1 | integer |
Index
of
primary
sequences
of
amino
acids
linked
through
peptide
bonds
in
order
of
decreasing
length.
Sequences
of
the
same
length
will
be
ordered
by
molecular
weight.
Subunits
that
have
identical
sequences
will
be
repeated
and
have
sequential
subscripts
|
|
sequence
|
Σ | 0..1 | string |
The
sequence
information
shall
be
provided
enumerating
the
amino
acids
from
N-
to
C-terminal
end
using
standard
single-letter
amino
acid
codes.
Uppercase
shall
be
used
for
L-amino
acids
and
lowercase
for
D-amino
acids.
Transcribed
SubstanceProteins
will
always
be
described
using
the
translated
sequence;
for
synthetic
peptide
containing
amino
acids
that
are
not
represented
with
a
single
letter
code
an
X
should
be
used
within
the
sequence.
The
modified
amino
acids
will
be
distinguished
by
their
position
in
the
sequence
|
|
length
|
Σ | 0..1 | integer |
Length
of
linear
sequences
of
amino
acids
contained
in
the
subunit
|
|
sequenceAttachment
|
Σ | 0..1 | Attachment |
The
sequence
information
shall
be
provided
enumerating
the
amino
acids
from
N-
to
C-terminal
end
using
standard
single-letter
amino
acid
codes.
Uppercase
shall
be
used
for
L-amino
acids
and
lowercase
for
D-amino
acids.
Transcribed
SubstanceProteins
will
always
be
described
using
the
translated
sequence;
for
synthetic
peptide
containing
amino
acids
that
are
not
represented
with
a
single
letter
code
an
X
should
be
used
within
the
sequence.
The
modified
amino
acids
will
be
distinguished
by
their
position
in
the
sequence
|
|
nTerminalModificationId
|
Σ | 0..1 | Identifier |
Unique
identifier
for
molecular
fragment
modification
based
on
the
ISO
11238
Substance
ID
|
|
nTerminalModification
|
Σ | 0..1 | string |
The
name
of
the
fragment
modified
at
the
N-terminal
of
the
SubstanceProtein
shall
be
specified
|
|
cTerminalModificationId
|
Σ | 0..1 | Identifier |
Unique
identifier
for
molecular
fragment
modification
based
on
the
ISO
11238
Substance
ID
|
|
cTerminalModification
|
Σ | 0..1 | string |
The
modification
at
the
C-terminal
shall
be
specified
|
|
Documentation
for
this
format
|
||||
See the Extensions for this resource
XML Template
<SubstanceProtein xmlns="http://hl7.org/fhir">
JSON Template
{
"resourceType" : "SubstanceProtein",
// from Resource: id, meta, implicitRules, and language
// from DomainResource: text, contained, extension, and modifierExtension
"sequenceType" : { CodeableConcept }, // The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
"numberOfSubunits" : <integer>, // Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
"disulfideLinkage" : ["<string>"], // The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
"subunit" : [{ // This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times
"subunit" : <integer>, // Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
"sequence" : "<string>", // The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
"length" : <integer>, // Length of linear sequences of amino acids contained in the subunit
"sequenceAttachment" : { Attachment }, // The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
"nTerminalModificationId" : { Identifier }, // Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
"nTerminalModification" : "<string>", // The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
"cTerminalModificationId" : { Identifier }, // Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
"cTerminalModification" : "<string>" // The modification at the C-terminal shall be specified
}]
}
Turtle Template
@prefix fhir: <http://hl7.org/fhir/> .
Changes from both R4 and R4B
| SubstanceProtein |
|
See the Full Difference for further information
This analysis is available for R4 as XML or JSON and for R4B as XML or JSON .
Additional definitions: Master Definition XML + JSON , XML Schema / Schematron + JSON Schema , ShEx (for Turtle ) + see the extensions , the spreadsheet version & the dependency analysis
Search parameters for this resource. See also the full list of search parameters for this resource , and check the Extensions registry for search parameters on extensions related to this resource. The common parameters also apply. See Searching for more information about searching in REST, messaging, and services.
(No search parameters for this resource)
FHIR
®©
HL7.org
2011+.
FHIR
R5
hl7.fhir.core#5.0.0
R6
hl7.fhir.core#6.0.0-ballot2
generated
on
Sun,
Mar
26,
2023
15:26+1100.
Mon,
Aug
12,
2024
16:59+0800.
Links:
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|
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|
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|
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|
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to
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to
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