This page is part of the FHIR Specification (v3.0.2: STU 3). The current version which supercedes this version is 5.0.0 . For a full list Continuous Integration Build of available versions, see FHIR (will be incorrect/inconsistent at times).
See the Directory of published versions . Page versions: R5 R4B R4 R3 R2

Using Codes Code Systems Value Sets Concept Maps Identifier Systems

4.3.1.466 4.4.1.142 Value Set ValueSet http://hl7.org/fhir/ValueSet/substance-code

  Maturity Level : 1

Patient Care Responsible Owner: Biomedical Research and Regulation Work Group

Informative

Use Context : Not Intended for Production use Country: World

This is a value set defined by the FHIR project. Summary

• Defining URL: Narrative http://hl7.org/fhir/ValueSet/substance-code
• XML Name:
• Substance Code JSON
• Definition: TTL This value set contains concept codes for specific substances. It includes codes from [SNOMED](http://snomed.info/sct) where concept is-a 105590001 (Substance (substance)) adn where concept is-a 373873005 (Pharmaceutical / biologic product (product))

Copyright: This value set includes content from SNOMED CT, which is copyright © 2002+ International Health Terminology Standards Development Organisation (IHTSDO), and distributed by agreement between IHTSDO and HL7. Implementer use

Official URL : Committee: http://hl7.org/fhir/ValueSet/substance-code Orders and Observations Work Group				OID: 2.16.840.1.113883.4.642.3.466 (for OID based terminology systems) Version : 6.0.0-ballot3
active as of SNOMED CT is not covered by this agreement. 2025-11-14				Computable Name : SubstanceCode
Source Resource Flags :				XML / JSON OID : 2.16.840.1.113883.4.642.3.473

This value set is used in the following places:

• Substance.ingredient.substance[x] Resource: Substance.code ( (CodeableReference(SubstanceDefinition) / Example )
• Resource: AllergyIntolerance.reaction.substance ( (CodeableConcept / Example )
• Extension Resource: Device.additive.type (CodeableReference(SubstanceDefinition) / Example )
• Resource: DeviceDefinition.material.substance (CodeableConcept / Example )
• Extension: http://hl7.org/fhir/StructureDefinition/allergyintolerance-substanceExposureRisk: substanceExposureRisk AISubstanceExposureRisk (( (CodeableConcept / Example )) )

4.3.1.466.1 4.4.1.142.1 Content Logical Definition

This value set includes contains concept codes from the following code systems: Include for specific substances. It includes codes from http://snomed.info/sct SNOMED where concept is-a 105590001 (Substance) (Substance (substance))

4.4.1.142.2 Content Logical Definition

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4.3.1.466.2 4.4.1.142.3 Expansion

This expansion generated 19 Apr 2017 14 Nov 2025

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See the full registry of value sets defined as part of FHIR.

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Explanation of the columns that may appear on this page:

Level Lvl	A few code lists that FHIR defines are hierarchical - each code is assigned a level. In this scheme, some codes For value sets, levels are under other codes, and imply that the mostly used to organize codes for user convenience, but may follow code they are under also applies system hierarchy - see Code System for further information
Source	The source of the definition of the code (when the value set draws in codes defined elsewhere)
Code	The code (used as the code in the resource instance). If the code is in italics, this indicates that the code is not selectable ('Abstract')
Display	The display (used in the display element of a Coding ). If there is no display, implementers should not simply display the code, but map the concept into their application
Definition	An explanation of the meaning of the concept
Comments	Additional notes about how to use the code