Chemotherapy Regimen (id = "KDN5")

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              http://www.ncbi.nlm.nih.gov/pubmed?term=%22The+Journal+of+urology%22%5BJour%5D+AND+1698%5Bpage%5D+AN
                D+2007%5Bpdat%5D+AND+Oudard+S%5Bauthor%5D
                  
              
            
          
          
            
            
              
                
                
                  
                    
                    
                  
                  
                    
                    
                  
                
              
              
                
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<PlanDefinition xmlns="http://hl7.org/fhir">
  <id value="KDN5"/> 
  <text> 
    <status value="additional"/> <div xmlns="http://www.w3.org/1999/xhtml">
      <table style="width: 100%;">
           <tr> 
          <td> 
            <div style="width: 200px; height: 100px; vertical-align: top;">National Comprehensive Cancer Network</div> 
          </td> 
          <td> 
            <h3> Chemotherapy Order Template</h3> 
            <h1> Kidney Cancer</h1> 
            <h2> Gemcitabine/CARBOplatin</h2> 
          </td> 
          <td style="text-align: right; vertical-align: top;">KDN5</td> 
           </tr> 
      </table> 
      <table style="width: 100%; border-top: 1px solid; border-bottom: 1px solid;">
           <tr> 
          <td style="width: 33%; border-right: 1px solid; vertical-align: top">
            <h4> INDICATION:</h4> 
            <p> Metastatic or Relapsed – Collecting Duct/Medullary Subtypes</p> 
          </td> 
          <td style="width: 34%; border-right: 1px solid; vertical-align: top">
            <h4> REFERENCES:</h4> 
            <ol> 
              <li> 
                <a href="http://www.example.org/professionals/physician_gls/PDF/kidney.pdf">NCCN Guidelines® for Kidney Cancer. V.3.2015.</a> 
              </li> 
              <li> 
                <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=%22The+Journal+of+urology%22%5BJour%5D+AND+1698%5Bpag
                e%5D+AND+2007%5Bpdat%5D+AND+Oudard+S%5Bauthor%5D">Oudard S, et al. 
                  <em> J Urol</em> . 2007;177(5):1698-702.                </a>                 <sup>                   <a href="http://www.example.org/OrderTemplates/PDF/appendix_E.pdf">a</a>                 </sup>               </li>             </ol>           </td>           <td style="width: 33%; vertical-align: top">            <h4> NCCN SUPPORTIVE CARE:</h4>             <ol>               <li>                 <i> Emetic Risk:</i>                 <table>                   <tr>                     <td> Day 1</td>                     <td> Moderate</td>                   </tr>                   <tr>                     <td> Day 8</td>                     <td> Low</td>                   </tr>                 </table>               </li>               <li>                 <i> Fever Neutropenia Risk:</i>                 <br/>  
                Refer to 
                <a href="http://www.example.org/professionals/physician_gls/PDF/myeloid_growth.pdf">NCCN Guidelines for Myeloid Growth Factors. V.2.2014</a>               </li>             </ol>           </td>            </tr>       </table>       <h4> CHEMOTHERAPY REGIMEN</h4>       <p>            <i> 21-day cycle for 6 cycles</i>       </p>       <ul>            <li> Gemcitabine 1250 mg/m          <sup> 2</sup>  IV over 30 minutes on Days 1 and 8          </li>            <li> CARBOplatin AUC 5 IV over 30 minutes on Day 1</li>       </ul>     </div>   </text>   <contained>     <ActivityDefinition>       <id value="1111"/>       <status value="draft"/>       <productCodeableConcept>         <coding>           <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>           <code value="12574"/>           <display value="gemcitabine"/>         </coding>         <text value="gemcitabine"/>       </productCodeableConcept>       <dosage>         <text value="1250 mg/m² IV over 30 minutes"/>         <timing>           <repeat>             <duration value="30"/>             <durationUnit value="min"/>           </repeat>         </timing>         <route>           <text value="IV"/>         </route>         <doseAndRate>           <type>             <coding>               <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>               <code value="ordered"/>               <display value="Ordered"/>             </coding>           </type>           <doseQuantity>             <value value="1250"/>             <unit value="mg/m²"/>           </doseQuantity>         </doseAndRate>       </dosage>     </ActivityDefinition>   </contained>   <contained>     <ActivityDefinition>       <id value="2222"/>       <status value="draft"/>       <productCodeableConcept>         <coding>           <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>           <code value="40048"/>           <display value="Carboplatin"/>         </coding>         <text value="CARBOplatin"/>       </productCodeableConcept>       <dosage>         <text value="AUC 5 IV over 30 minutes"/>         <timing>           <repeat>             <duration value="30"/>             <durationUnit value="min"/>           </repeat>         </timing>         <route>           <text value="IV"/>         </route>         <doseAndRate>           <type>             <coding>               <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>               <code value="ordered"/>               <display value="Ordered"/>             </coding>           </type>           <doseQuantity>             <extension url="http://example.org/fhir/AUC-dose">              <valueInteger value="5"/>             </extension>           </doseQuantity>         </doseAndRate>       </dosage>     </ActivityDefinition>   </contained>   <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">    <valueCode value="cds"/>   </extension>   <identifier>     <system value="http://example.org/ordertemplates"/>     <value value="KDN5"/>   </identifier>   <identifier>     <system value="urn:ietf:rfc:3986"/>     <value value="urn:oid:2.16.840.1.113883.4.642.11.21"/>   </identifier>   <version value="1"/>   <name value="GemcitabineCARBOplatin"/>   <title value="Gemcitabine/CARBOplatin"/>   <type>     <text value="Chemotherapy Order Template"/>   </type>   <status value="draft"/>   <experimental value="true"/>   <publisher value="HL7 International / Clinical Decision Support"/>   <contact>     <telecom>       <system value="url"/>       <value value="http://www.hl7.org/Special/committees/dss"/>     </telecom>   </contact>   <description value="Gemcitabine/CARBOplatin"/>   <useContext>     <code>       <system value="http://example.org/fhir/CodeSystem/indications"/>       <code value="treamentSetting-or-diseaseStatus"/>     </code>     <valueCodeableConcept>       <text value="Metastatic"/>     </valueCodeableConcept>   </useContext>   <useContext>     <code>       <system value="http://example.org/fhir/CodeSystem/indications"/>       <code value="disease-or-histology"/>     </code>     <valueCodeableConcept>       <text value="Collecting Duct/Medullary Subtypes"/>     </valueCodeableConcept>   </useContext>   <useContext>     <code>       <system value="http://terminology.hl7.org/CodeSystem/usage-context-type"/>       <code value="focus"/>     </code>     <valueCodeableConcept>       <text value="Kidney Cancer"/>     </valueCodeableConcept>   </useContext>   <useContext>     <code>       <system value="http://example.org/fhir/CodeSystem/indications"/>       <code value="treatmentSetting-or-diseaseStatus"/>     </code>     <valueCodeableConcept>       <text value="Relapsed"/>     </valueCodeableConcept>   </useContext>   <useContext>     <code>       <system value="http://example.org/fhir/CodeSystem/indications"/>       <code value="disease-or-histology"/>     </code>     <valueCodeableConcept>       <text value="Collecting Duct/Medullary Subtypes"/>     </valueCodeableConcept>   </useContext>   <useContext>     <code>       <system value="http://terminology.hl7.org/CodeSystem/usage-context-type"/>       <code value="focus"/>     </code>     <valueCodeableConcept>       <text value="Kidney Cancer – Collecting Duct/Medullary Subtypes - Metastatic"/>     </valueCodeableConcept>   </useContext>   <copyright value="All rights reserved."/>   <approvalDate value="2016-07-27"/>   <lastReviewDate value="2016-07-27"/>   <author>     <name value="Lee Surprenant"/>   </author>   <relatedArtifact>     <type value="derived-from"/>     <display value="NCCN Guidelines for Kidney Cancer. V.2.2016"/>     <document>       <url value="http://www.example.org/professionals/physician_gls/PDF/kidney.pdf"/>     </document>   </relatedArtifact>   <relatedArtifact>     <type value="citation">      <extension url="http://example.org/fhir/regimenReferenceType">        <valueCode value="a"/>       </extension>     </type>     <citation value="Oudard S, et al. J Urol. 2007;177(5):1698-702"/>     <document>       <url value="http://www.ncbi.nlm.nih.gov/pubmed/17437788"/>     </document>   </relatedArtifact>   <action>     <selectionBehavior value="exactly-one"/>     <action>       <selectionBehavior value="all"/>       <action>         <groupingBehavior value="sentence-group"/>         <selectionBehavior value="exactly-one"/>         <action id="cycle-definition-1">          <textEquivalent value="21-day cycle for 6 cycles"/>           <timingTiming>             <repeat>               <count value="6"/>               <duration value="21"/>               <durationUnit value="d"/>             </repeat>           </timingTiming>           <action id="action-1">            <extension url="http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle">              <extension url="day">                <valueInteger value="1"/>               </extension>               <extension url="day">                <valueInteger value="8"/>               </extension>             </extension>             <textEquivalent value="Gemcitabine 1250 mg/m² IV over 30 minutes on days 1 and 8"/>             <definitionCanonical value="#1111"/>           </action>           <action id="action-2">            <extension url="http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle">              <extension url="day">                <valueInteger value="1"/>               </extension>             </extension>             <textEquivalent value="CARBOplatin AUC 5 IV over 30 minutes on Day 1"/>             <relatedAction>               <targetId value="action-1"/>               <relationship value="concurrent-with-start"/>             </relatedAction>             <definitionCanonical value="#2222"/>           </action>         </action>       </action>     </action>   </action> 


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