Oral Chemotherapy Example - Manufactured Product - Xeloda - includes a reference to a substance in ingredient element

{
  "resourceType": "Medication",
  "id": "medexample015",
  "text": {
    "status": "generated",
    "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative with Details</b></p><p><b>id</b>: medexample015</p><p><b>contained</b>: , </p><p><b>code</b>: Capecitabine 500mg oral tablet (Xeloda) <span>(Details : {RxNorm code '213293' = 'Xeloda 500 MG Oral Tablet', given as 'Capecitabine 500mg oral tablet (Xeloda)'})</span></p><p><b>manufacturer</b>: id: org2; name: Gene Inc</p><p><b>form</b>: Tablet dose form (qualifier value) <span>(Details : {SNOMED CT code '385055001' = 'Tablet', given as 'Tablet dose form (qualifier value)'})</span></p><h3>Ingredients</h3><table><tr><td>-</td><td><b>Item[x]</b></td><td><b>Strength</b></td></tr><tr><td>*</td><td>id: sub04; Capecitabine (substance) <span>(Details : {SNOMED CT code '386906001' = 'Capecitabine', given as 'Capecitabine (substance)'})</span></td><td>500 mg<span> (Details: UCUM code mg = 'mg')</span>/1 TAB<span> (Details: http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm code TAB = 'Tablet')</span></td></tr></table><h3>Batches</h3><table><tr><td>-</td><td><b>LotNumber</b></td><td><b>ExpirationDate</b></td></tr><tr><td>*</td><td>9494788</td><td>22/05/2017</td></tr></table></div>"

  "resourceType" : "Medication",
  "id" : "medexample015",
  "contained" : [{
    "resourceType" : "Organization",
    "id" : "mmanu",
    "name" : "Medication Manufacturer"

  },
  "contained": [
    {
      "resourceType": "Organization",
      "id": "org2",
      "name": "Gene Inc"
    },
    {
      "resourceType": "Substance",
      "id": "sub04",
      "code": {
        "coding": [
          {
            "system": "http://snomed.info/sct",
            "code": "386906001",
            "display": "Capecitabine (substance)"
          }
        ]

  {
    "resourceType" : "Substance",
    "id" : "sub04",
    "code" : {
      "concept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "386906001",
          "display" : "Capecitabine (substance)"
        }]

      }
    }
  ],
  "code": {
    "coding": [
      {
        "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
        "code": "213293",
        "display": "Capecitabine 500mg oral tablet (Xeloda)"
      }
    ]

  }],
  "code" : {
    "coding" : [{
      "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
      "code" : "213293",
      "display" : "capecitabine 500 MG Oral Tablet [Xeloda]"
    }]

  },
  "manufacturer": {
    "reference": "#org2"

  "marketingAuthorizationHolder" : {
    "reference" : "#mmanu"

  },
  "form": {
    "coding": [
      {
        "system": "http://snomed.info/sct",
        "code": "385055001",
        "display": "Tablet dose form (qualifier value)"
      }
    ]

  "doseForm" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "385055001",
      "display" : "Tablet (basic dose form)"
    }]

  },
  "ingredient": [
    {
      "itemReference": {
        "reference": "#sub04"

  "ingredient" : [{
    "item" : {
      "reference" : {
        "reference" : "#sub04"
      }
    },
    "strengthRatio" : {
      "numerator" : {
        "value" : 500,
        "system" : "http://unitsofmeasure.org",
        "code" : "mg"

      },
      "strength": {
        "numerator": {
          "value": 500,
          "system": "http://unitsofmeasure.org",
          "code": "mg"
        },
        "denominator": {
          "value": 1,
          "system": "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
          "code": "TAB"
        }

      "denominator" : {
        "value" : 1,
        "system" : "http://terminology.hl7.org/CodeSystem/v3-orderableDrugForm",
        "code" : "TAB"

      }
    }
  ],
  "batch": {
    "lotNumber": "9494788",
    "expirationDate": "2017-05-22"

  }],
  "instance" : {
    "lotNumber" : "9494788",
    "expirationDate" : "2017-05-22"

  }
}