Drug-drug interaction between prescription and medication statement (id = "ddi")

<?xml version="1.0" encoding="UTF-8"?>

<DetectedIssue xmlns="http://hl7.org/fhir">
  <id value="ddi"/> 
  <text> 
    
    

    <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml">
      <p> <b> Severity: High</b>  - Risk of internal bleeding</p> 
      <p> Those who take acetaminophen along with the widely used blood-thinning drug warfarin
         may face the risk of serious internal bleeding. People on warfarin who take acetaminophen
         for at least seven days in a row should be closely watched for bleeding.</p> 
      <ul> 
        <li> <a href="MedicationStatement/tylenol">500 mg Acetaminophen tablet 1/day, PRN since 2010</a> </li> 
        <li> <a href="MedicationRequest/warfarin">Warfarin 1 MG TAB prescribed Jan. 5, 2014</a> </li> 
      </ul> 
      <p> Mitigation: Jan 5, 2014 by Dr. Adam Careful: </p> 
      <p> Asked patient to discontinue regular use of Tylenol and to consult with clinician
         if they need to resume to allow appropriate INR monitoring</p> 
    </div> 
  </text> 
  <status value="final"/> 
  <category> 
    <coding> 
      <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/> 
      <code value="DRG"/> 
      <display value="Drug Interaction Alert"/> 
    </coding> 
  </category> 
  <code> 
    <coding> 
      <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/> 
      <code value="DRG"/> 
      <display value="Drug Interaction Alert"/> 
    </coding> 
  </code> 
  

  <severity> 
    <coding> 
      <system value="http://hl7.org/fhir/detectedissue-severity"/> 
      <code value="high"/> 
      <display value="High"/> 
    </coding> 
  </severity> 
  <subject> 
    <reference value="Device/example"/> 
  </subject> 
  <identifiedDateTime value="2014-01-05"/> 
  <implicated> 
    <reference value="MedicationStatement/example001"/> 
    <display value="500 mg Acetaminophen tablet 1/day, PRN since 2010"/> 
  </implicated> 
  <implicated> 
    <reference value="MedicationRequest/medrx0331"/> 
    <display value="Warfarin 1 MG TAB prescribed Jan. 15, 2015"/> 
  </implicated> 
  <detail value="Risk of internal bleeding.  Those who take acetaminophen along with the widely
   used blood-thinning drug warfarin may face the risk of serious internal bleeding.
   People on warfarin who take acetaminophen for at least seven days in a row should
   be closely watched for bleeding."/> 
  <mitigation> 
    <action> 
      <coding> 
        <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/> 
        <code value="13"/> 
        <display value="Stopped Concurrent Therapy"/> 
      </coding> 
      <text value="Asked patient to discontinue regular use of Tylenol and to consult with clinician
       if they need to resume to allow appropriate INR monitoring"/> 
    </action> 
    <date value="2014-01-05"/> 
    <author> 
      <reference value="Practitioner/example"/> 
      <display value="Dr. Adam Careful"/> 
    </author> 
  </mitigation> 


</

DetectedIssue

>