Drug-drug interaction between prescription and medication statement (id = "ddi")

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      Those who take acetaminophen along with the widely used blood-thinning drug warfarin may
         face the risk of serious internal bleeding. People on warfarin who take acetaminophen
         for at least seven days in a row should be closely watched for bleeding.
      
        
        
      
      
      Asked patient to discontinue regular use of Tylenol and to consult with clinician if they
         need to resume to allow appropriate INR monitoring
    
  
  
  
    
      
      
      
    
  
  
  
  
    
  
  
    
    
  
  
    
    
  
  Risk of internal bleeding.  Those who take acetaminophen along with the widely used blood-thinning
   drug warfarin may face the risk of serious internal bleeding. People on warfarin who take
   acetaminophen for at least seven days in a row should be closely watched for bleeding.
  
    
      
        
        
        
      
      Asked patient to discontinue regular use of Tylenol and to consult with clinician if they
       need to resume to allow appropriate INR monitoring
    
    
    
      
      
    
  

<DetectedIssue xmlns="http://hl7.org/fhir">
  <id value="ddi"/> 
  <text> 
    <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml">
      <p> <b> Severity: High</b>  - Risk of internal bleeding</p> 
      <p> Those who take acetaminophen along with the widely used blood-thinning drug warfarin
         may face the risk of serious internal bleeding. People on warfarin who take acetaminophen
         for at least seven days in a row should be closely watched for bleeding.</p> 
      <ul>         <li> <a href="MedicationStatement/tylenol">500 mg Acetaminophen tablet 1/day, PRN since 2010</a> </li>         <li> <a href="MedicationRequest/warfarin">Warfarin 1 MG TAB prescribed Jan. 5, 2014</a> </li>       </ul>       <p> Mitigation: Jan 5, 2014 by Dr. Adam Careful: </p>       <p> Asked patient to discontinue regular use of Tylenol and to consult with clinician

         if they need to resume to allow appropriate INR monitoring</p> 
    </div>   </text>   <status value="final"/>   <category>     <coding>       <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/>       <code value="DRG"/>       <display value="Drug Interaction Alert"/>     </coding>   </category>   <code>     <coding>       <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/>       <code value="DRG"/>       <display value="Drug Interaction Alert"/>     </coding>   </code>   <severity>     <coding>       <system value="http://hl7.org/fhir/detectedissue-severity"/>       <code value="high"/>       <display value="High"/>     </coding>   </severity>   <subject>     <reference value="Device/example"/>   </subject>   <identifiedDateTime value="2014-01-05"/>   <implicated>     <reference value="MedicationStatement/example001"/>     <display value="500 mg Acetaminophen tablet 1/day, PRN since 2010"/>   </implicated>   <implicated>     <reference value="MedicationRequest/medrx0331"/>     <display value="Warfarin 1 MG TAB prescribed Jan. 15, 2015"/>   </implicated>   <detail value="Risk of internal bleeding.  Those who take acetaminophen along with the widely

   used blood-thinning drug warfarin may face the risk of serious internal bleeding.
   People on warfarin who take acetaminophen for at least seven days in a row should
   be closely watched for bleeding."/> 
  <mitigation>     <action>       <coding>         <system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/>         <code value="13"/>         <display value="Stopped Concurrent Therapy"/>       </coding>       <text value="Asked patient to discontinue regular use of Tylenol and to consult with clinician

       if they need to resume to allow appropriate INR monitoring"/> 
    </action>     <date value="2014-01-05"/>     <author>       <reference value="Practitioner/example"/>       <display value="Dr. Adam Careful"/>     </author>   </mitigation> 


</

DetectedIssue

>