A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.

Business identifier for this issue.

indication | contraindication | interaction | undesirable-effect | warning.

A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy and Lactation", "Overdose", "Effects on Ability to Drive and Use Machines".

The medication, product, substance, device, procedure etc. for which this is an indication, contraindication, interaction, undesirable effect, or warning.

Whether this is a current issue or one that has been retired etc.

Describe the possible undesirable effects (negative outcomes) from the use of the medicinal product as treatment.

The situation in which the undesirable effect may manifest.

High level classification of the effect.

How often the effect is seen.

Actions for managing the undesirable effect.

Specifics for when this is a contraindication. an indication.

The situation that is being documented as contraindicating against an indication for this item.

The status of the disease or symptom for the contraindication, indication, for example "chronic" or "metastatic".

A comorbidity (concurrent condition) or coinfection. coinfection as part of the indication. Where this repeats it means that any one of these is relevant, rather than all of them needing to be present.

The indication which this is a contraindication for. intended effect, aim or strategy to be achieved.

Timing or duration information, that may be associated with use with the indicated condition e.g. Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months).

An unwanted side effect or negative outcome that may happen if you use the drug (or other subject of this resource) for this indication.

An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements.

The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

Information about the use of the medicinal product in relation to other therapies described as part of the contraindication.

The type of relationship between the medicinal product indication or contraindication and another therapy.

Reference to a specific medication (active substance, medicinal product or class of products, biological, food etc.) as part of an indication or contraindication.

Specifics for when this is an indication. a contraindication.

The situation that is being documented as an indication for contraindicating against this item.

The status of the disease or symptom for the indication, contraindication, for example "chronic" or "metastatic".

A comorbidity (concurrent condition) or coinfection as part coinfection. Where this repeats it means that any one of the indication. these is relevant, rather than all of them needing to be present.

The intended effect, aim or strategy to be achieved. indication which this is a contraindication for.

Timing or duration information, An expression that may be associated with use with returns true or false, indicating whether the indicated condition e.g. Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months). indication is applicable or not, after having applied its other elements.

The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

An unwanted side effect or negative outcome that may happen if you use the drug (or other subject of this resource) Actions for this indication. managing the contraindication.

Information about the use of the medicinal product in relation to other therapies described as part of the indication. contraindication.

Specifics for when this is an interaction.

The specific medication, product, food, substance etc. or laboratory test that interacts.

The specific medication, product, food, substance etc. or laboratory test that interacts.

The type of route by which the item is administered to cause the interaction e.g. drug-drug interaction, drug-food interaction, drug-lab test interaction.

The effect type of the interaction e.g. drug-drug interaction, for example "reduced gastric absorption of primary medication". drug-food interaction, drug-lab test interaction.

The incidence effect of the interaction, e.g. theoretical, observed. for example "reduced gastric absorption of primary medication".

Actions for managing The incidence of the interaction. interaction, e.g. theoretical, observed.

Logic used by Actions for managing the clinical use definition. interaction.

The situation in which severity of the undesirable effect may manifest. interaction.

High level classification of the effect. The population group to which this applies.

How often Logic used by the effect is seen. clinical use definition.

A critical piece of information about environmental, health or physical risks or hazards that serve as caution to the user. For example 'Do not operate heavy machinery', 'May cause drowsiness', or 'Get medical advice/attention if you feel unwell'.

A textual definition of this warning, with formatting.

A coded or unformatted textual definition of this warning.